| 產(chǎn)品編號(hào) | bs-12603R |
| 英文名稱(chēng) | Rabbit Anti-PDLIM7 antibody |
| 中文名稱(chēng) | PDZ和LIM結(jié)構(gòu)域結(jié)合蛋白7抗體 |
| 別 名 | 1110003B01Rik; Enigma; LIM domain protein; LIM domain protein enigma; LIM mineralization protein 1; Lim mineralization protein 3; LIM mineralization protein; LMP 1; LMP; LMP1; LMP3; PDLI7_HUMAN; PDLIM 7; Pdlim7; PDZ and LIM doamin protein 7; PDZ and LIM domain 7; PDZ and LIM domain protein 7; Protein enigma. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 細(xì)胞骨架 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Zebrafish,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PDLIM7: 331-430/457 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] Function: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway. Subcellular Location: Cytoplasm. Cytoplasm > cytoskeleton. Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Co-localizes with TBX4 and TBX5 to actin filaments. Tissue Specificity: Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletal muscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver. Similarity: Contains 3 LIM zinc-binding domains. Contains 1 PDZ (DHR) domain. SWISS: Q9NR12 Gene ID: 9260 Database links: Entrez Gene: 100712754 Guinea pig Entrez Gene: 100058356 Horse Entrez Gene: 9260 Human Entrez Gene: 67399 Mouse Entrez Gene: 393813 Zebrafish Omim: 605903 Human SwissProt: Q9NR12 Human SwissProt: Q3TJD7 Mouse SwissProt: Q6P7E4 Zebrafish Unigene: 533040 Human Unigene: 275648 Mouse Unigene: 7274 Rat Unigene: 118064 Zebrafish Unigene: 121170 Zebrafish Unigene: 85085 Zebrafish |
