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Rabbit Anti-TCF7L1  antibody (bs-12891R)  
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產(chǎn)品編號 bs-12891R
英文名稱 Rabbit Anti-TCF7L1  antibody
中文名稱 轉(zhuǎn)錄因子7樣蛋白1抗體
別    名 bHLHb21; HMG box transcription factor 3; HMG box transcription factor; OTTMUSP00000023419; T cell factor 3; TCF 3; TCF-3; TCF3; Tcf7l1; TF7L1_HUMAN; Transcription factor 7 like 1 (T-cell specific, HMG-box); Transcription factor 7 like 1; Transcription factor 7-like 1.  
研究領(lǐng)域 干細胞  轉(zhuǎn)錄調(diào)節(jié)因子  淋巴細胞  t-淋巴細胞  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Cow,Dog)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 63kDa
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TCF7L1: 51-150/588 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

Function:
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

Subcellular Location:
Nucleus.

Tissue Specificity:
Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.

Similarity:
Belongs to the TCF/LEF family.
Contains 1 HMG box DNA-binding domain.

SWISS:
Q9HCS4

Gene ID:
83439

Database links:

Entrez Gene: 83439 Human

Entrez Gene: 21415 Mouse

Entrez Gene: 312451 Rat

Omim: 604652 Human

SwissProt: Q9HCS4 Human

SwissProt: Q9Z1J1 Mouse

Unigene: 516297 Human

Unigene: 440067 Mouse



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Human skin); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TCF7L1) Polyclonal Antibody, Unconjugated (bs-12891R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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