| 產(chǎn)品編號(hào) | bs-9117R |
| 英文名稱 | Rabbit Anti-Neurexin-3-beta antibody |
| 中文名稱 | 軸突蛋白3 beta抗體 |
| 別 名 | Neurexin-3-beta; Neurexin III-beta; Neurexin-3-beta, soluble form; NRX3B_HUMAN; NRXN3; KIAA0743. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 細(xì)胞粘附分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Cow,Chicken) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 65kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neurexin-3-beta: 121-220/637 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012] Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis. Subunit: The cytoplasmic C-terminal region binds to CASK. Binds to neuroligins NLGN1, NLGN2 and NLGN3. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Expressed in the blood vessel walls (at protein level). Post-translational modifications: Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides. Similarity: Belongs to the neurexin family. Contains 1 laminin G-like domain. SWISS: Q9HDB5 Gene ID: 9369 Database links: Entrez Gene: 9369 Human Entrez Gene: 18191 Mouse Omim: 600567 Human SwissProt: Q9HDB5 Human SwissProt: Q9Y4C0 Human SwissProt: Q6P9K9 Mouse SwissProt: Q8C985 Mouse SwissProt: Q8CCT8 Mouse |
| 產(chǎn)品圖片 |
Sample:
U251 Cell (Human) Lysate at 40 ug
Hela Cell (Human) Lysate at 40 ug
Primary: Anti- Neurexin-3-beta (bs-9117R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 65/130 kD
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