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Rabbit Anti-LY6E  antibody (bs-20838R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-20838R
英文名稱 Rabbit Anti-LY6E  antibody
中文名稱 T淋巴細(xì)胞激活蛋白6E抗體
別    名 Ly-6E ; LY6E_HUMAN ; LY6E_MOUSE ; Lymphocyte antigen 6E ; Retinoic acid-induced gene E protein ; RIG-E ; RIGE; SCA2; TSA1; 9804; SCA-2 ; Stem cell antigen 2 ; Thymic shared antigen 1 ; TSA-1 .  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  干細(xì)胞  淋巴細(xì)胞  t-淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse (predicted: Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 14kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse LY6E: 31-80/136 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]

Function:
GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity).
Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482).
Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity).

Tissue Specificity:
Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.

Similarity:
Contains 1 UPAR/Ly6 domain.

SWISS:
Q64253

Gene ID:
17069

Database links:

Entrez Gene: 17069 Mouse

SwissProt: Q64253 Mouse

Unigene: 788 Mouse

Unigene: 3321 Rat



產(chǎn)品圖片
Sample:Thymus (Mouse)Lysate at 40 ug Primary: Anti-LY6E(bs-20838R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 14kD Observed band size: 14kD
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