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Rabbit Anti-CD63  antibody (bs-23032R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-23032R
英文名稱 Rabbit Anti-CD63  antibody
中文名稱 黑色素瘤相關(guān)抗原抗體
別    名 Lysosomal associated membrane protein 3; CD63 antigen; CD63 antigen melanoma 1 antigen; CD63 molecule; granulophysin; LAMP 3; LAMP3; lysosome associated membrane glycoprotein 3; CD 63; CD63 antigen (melanoma 1 antigen); CD63_HUMAN; gp55; granulophysin; LAMP-3; LIMP; Lysosomal-associated membrane protein 3; Melanoma-associated antigen ME491; NGA; Ocular melanoma-associated antigen; PTLGP40; Tetraspanin-30; Tspan-30; Mast cell antigen AD1; ME491; melanoma 1 antigen; Melanoma associated antigen ME491; Melanoma associated antigen MLA1; MGC72893; MLA 1; MLA1; ocular melanoma associated antigen; OMA81H; Tetraspanin 30; Tspan 30; TSPAN30; Tumor biomarkers; Platelets markers.  
Specific References  (1)     |     bs-23032R has been referenced in 1 publications.
[IF=14.976] Qinyu Ma. et al. Small extracellular vesicles deliver osteolytic effectors and mediate cancer‐induced osteolysis in bone metastatic niche. J Extracell Vesicles. 2021 Feb;10(4):e12068  WB ;  Mouse.  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 26kDa
檢測(cè)分子量 30-50
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CD63: 101-180/238 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Function:
This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules.

Tissue Specificity:
Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

SWISS:
P41731

Gene ID:
12512

Database links:

Entrez Gene: 404156 Cow

Entrez Gene: 967 Human

Entrez Gene: 12512 Mouse

Entrez Gene: 100008988 Rabbit

Omim: 155740 Human

SwissProt: Q9XSK2 Cow

SwissProt: P08962 Human

SwissProt: P41731 Mouse

SwissProt: Q28709 Rabbit

Unigene: 445570 Human

Unigene: 371552 Mouse

Unigene: 416079 Mouse



CD63為溶酶體膜糖蛋白也是一種細(xì)胞表面糖蛋白,可表達(dá)在多種細(xì)胞的表面和胞漿內(nèi),血小板活化后即轉(zhuǎn)移至膜表面。
CD63—又稱黑色素瘤相關(guān)抗原MLA1和整合素形成復(fù)合物。是血液血小板活化的標(biāo)志。與一些腫瘤的進(jìn)展也有關(guān)聯(lián)。
產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human tonsil); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD63 ) Polyclonal Antibody, Unconjugated (bs-23032R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD63 ) Polyclonal Antibody, Unconjugated (bs-23032R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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