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Rabbit Anti-CD163  antibody (bs-23127R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-23127R
英文名稱 Rabbit Anti-CD163  antibody
中文名稱 CD163抗體
別    名 Scavenger receptor cysteine-rich type 1 protein M130; CD 163; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; M130; M130 antigen precursor; Macrophage associated antigen; MM130; C163A_HUMAN.  
研究領域 心血管  免疫學  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 121kDa
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD163: 551-650/1156 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Function:
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

Subcellular Location:
Secreted and Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.

Tissue Specificity:
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Post-translational modifications:
A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.

Similarity:
Contains 9 SRCR domains.

SWISS:
Q86VB7

Gene ID:
9332

Database links:

Entrez Gene: 9332 Human

Entrez Gene: 93671 Mouse

Entrez Gene: 312701 Rat

Omim: 605545 Human

SwissProt: Q86VB7 Human

SwissProt: Q2VLH6 Mouse

Unigene: 504641 Human

Unigene: 37426 Mouse

Unigene: 203204 Rat



CD163是SRCR超家族成員之一,又稱為血紅蛋白清道夫受體(hemoglobin scavenger receptor, HbSR)、M130或p155。CD163的表達水平受很多因素調節(jié),糖皮質激素及抗炎介質如IL-10以及IL-6能上調CD163, 而促炎介質如脂多糖(lipopolysaccharide, LPS)、γ-干擾素(interferon-γ, IFN-γ)以及TNF-α則抑制CD163表達。 CD163是一種I型膜蛋白,又稱為M130抗原、Ber-Mac3、Ki-M8或SM4。CD163限制性表達于單核/巨噬細胞系,所有循環(huán)系統(tǒng)的單核細胞和大多數(shù)組織(除外淋巴濾泡套區(qū)和生發(fā)中心)的巨噬細胞均陽性表達,主要用于單核/巨噬細胞的檢測。
產品圖片
Sample: Lymph node (Mouse) Lysate at 40 ug Primary: Anti-CD163 (bs-23127R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 121 kD Observed band size: 130 kD
Sample: Hela(Human) Cell Lysate at 30 ug Primary: Anti-CD163 (bs-23127R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 121 kD Observed band size: 130 kD
Sample: Lane 1: Hela (Human) Cell Lysate at 30 ug Lane 2: HL60 (Human) Cell Lysate at 30 ug Primary: Anti-CD163 (bs-23127R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 110 kD Observed band size: 110 kD
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