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Rabbit Anti-Ctip2  antibody (bs-23677R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-23677R
英文名稱 Rabbit Anti-Ctip2  antibody
中文名稱 B淋巴細(xì)胞白血病/淋巴瘤11B抗體
別    名 B cell lymphoma/leukemia 11B; B-cell CLL/Lymphoma 11B; B-cell lymphoma/leukemia 11B; BC11B_HUMAN; BCL-11B; Bcl11B; COUP-TF interacting protein 2; COUP-TF-interacting protein 2; Ctip 2; hRit1; MS1029; Radiation induced tumor suppressor gene 1; Radiation induced tumor suppressor gene 1 protein; Radiation-induced tumor suppressor gene 1 protein; Rit 1; Rit1.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  淋巴細(xì)胞  b-淋巴細(xì)胞  鋅指蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 95kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ctip2 : 331-4630/894 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Function:
Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.

Subunit:
Interacts with TFCOUP1, SIRT1, ARP1 and EAR2

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.

Similarity:
Contains 6 C2H2-type zinc fingers.

SWISS:
Q9C0K0

Gene ID:
64919

Database links:

Entrez Gene: 64919 Human

Entrez Gene: 58208 Mouse

Entrez Gene: 314423 Rat

Omim: 606558 Human

SwissProt: Q9C0K0 Human

SwissProt: Q99PV8 Mouse

Unigene: 709690 Human

Unigene: 392694 Mouse



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Ctip2) Polyclonal Antibody, Unconjugated (bs-23677R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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