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Rabbit Anti-FGF21  antibody (bs-23679R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-23679R
英文名稱 Rabbit Anti-FGF21  antibody
中文名稱 成纖維細胞生長因子21抗體
別    名 Fibroblast growth factor 21; FGF 21; FGF-21; FGFL; FGF21_HUMAN.  
Specific References  (1)     |     bs-23679R has been referenced in 1 publications.
[IF=3.598] Xu X et al. Potential?biomarker?of?fibroblast?growth?factor?21?in?valproic?acid-treated?livers. Biofactors. 2019 May 23.  IHC-P ;  Mouse.  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  信號轉(zhuǎn)導  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 20kDa
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FGF21: 1-100/209 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 FGF21 is a growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes.

Function:
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.

Subcellular Location:
Secreted.

Tissue Specificity:
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.

SWISS:
Q9NSA1

Gene ID:
26291

Database links:

Entrez Gene: 26291 Human

Entrez Gene: 56636 Mouse

Entrez Gene: 170580 Rat

Omim: 609436 Human

SwissProt: Q9NSA1 Human

SwissProt: Q9JJN1 Mouse

Unigene: 283015 Human

Unigene: 143736 Mouse



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FGF21) Polyclonal Antibody, Unconjugated (bs-23679R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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