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Rabbit Anti-TRPV1  antibody (bs-23926R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-23926R
英文名稱 Rabbit Anti-TRPV1  antibody
中文名稱 辣椒素受體抗體
別    名 Capsaicin receptor; DKFZp434K0220; Osm 9 like TRP channel 1; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; TRPV 1; TRPV1; Vanilloid receptor 1; Vanilloid receptor subtype 1; VR 1; VR1; TRPV1_HUMAN.  
Specific References  (9)     |     bs-23926R has been referenced in 9 publications.
[IF=15.84] Yuanyuan He. et al. Injectable Affinity and Remote Magnetothermal Effects of Bi-Based Alloy for Long-Term Bone Defect Repair and Analgesia. 2021 May 20  IHC ;  Rat.  
[IF=6.59] Yuge Jiang. et al. Eugenol improves high-fat diet/streptomycin-induced type 2 diabetes mellitus (T2DM) mice muscle dysfunction by alleviating inflammation and increasing muscle glucose uptake.. FRONT NUTR. 2022 Nov;9:1039753-1039753  WB ;  Mouse.  
[IF=6.208] Lisha Chen. et al. Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCε/P38MAPK/NF-κB Signaling Pathway in Rats. INT J MOL SCI. 2022 Jan;23(22):14141  WB ;  Rat.  
[IF=5.924] Hung-Jen Wang. et al. Molecular Effects of Low-Intensity Shock Wave Therapy on L6 Dorsal Root Ganglion/Spinal Cord and Blood Oxygenation Level-Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Changes in Capsaicin-Induced Prostatitis Rat Models. INT J MOL SCI. 2022 Jan;23(9):4716  WB,IF ;  Rat.  
[IF=5.195] Qian Yu. et al. Yuhong ointment ameliorates inflammatory responses and wound healing in scalded mice. J ETHNOPHARMACOL. 2023 Apr;306:116118  IHC ;  Mouse.  
[IF=4.924] Haiyang Wang. et al. A Pilot Study of Clinical Evaluation and Formation Mechanism of Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease Patients in Remission. J Neurogastroenterol. 2021 Oct 30; 27(4): 612–625  WB ;  Human.  
[IF=2.946] Youyou Lu. et al. Mechanisms underlying the promotion of 5‐hydroxytryptamine secretion in enterochromaffin cells of constipation mice by Bifidobacterium and Lactobacillus. 2021 Jan 15  WB ;  Mouse.  
[IF=2.65] Zong Chunxiao. et al. Huayu Sanjie Enema Liquid Relieves Pain in Endometriosis Model Rats by Inhibiting Inflammation, Peripheral Sensitization, and Pelvic Adhesion. EVID-BASED COMPL ALT. 2022;2022:5256578  WB ;  Rat.  
[IF=2.067] Gao Y et al. Chrysene accelerates the proceeding of chronic obstructive pulmonary disease with the aggravation of inflammation and apoptosis in cigarette smoke exposed mice:Hum Exp Toxicol.2020 Dec 20;960327120979343.  IHC ;  Mouse.  
研究領(lǐng)域 腫瘤  心血管  免疫學  細胞凋亡  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 92kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRPV1 : 141-240/839 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The detection of noxious stimuli (chemical, mechanical, or thermal) occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke a perception of pain which initiates appropriate protective reflexes. The receptor for capsaicin, VR1 (vanilloid receptor 1; TRPV1 is a nonselective cation channel that resembles members of the transient receptor potential (TRP) family of ion channels. The vanilloid receptor 1 protein functions both as a receptor for capsaicin and a transducter of noxious thermal stimuli. VR1 protein is localized to small-diameter sensory neurons within the dorsal root ganglia and nerve terminals in the dorsal horn.

Function:
Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons.

Subunit:
Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PIRT, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex.

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendritic spine membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).

Post-translational modifications:
Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
Contains 6 ANK repeats.

SWISS:
Q8NER1

Gene ID:
7442

Database links:

Entrez Gene: 7442 Human

Entrez Gene: 193034 Mouse

Entrez Gene: 83810 Rat

Omim: 602076 Human

SwissProt: Q8NER1 Human

SwissProt: Q704Y3 Mouse

SwissProt: O35433 Rat

Unigene: 579217 Human

Unigene: 655380 Human

Unigene: 447485 Mouse

Unigene: 3073 Rat



辣椒素受體(Vanilloid receptor subtype 1)是機體的一個重要的損傷性感受蛋白,參與了多種生理活動和病理過程,起到對中樞和外周水平疼痛的形成,還可以激活神經(jīng)纖維末端的辣椒素受體,調(diào)節(jié)外周血管的舒縮,影響血壓,對缺血心肌起到保護作用; VR1還參與哮喘的發(fā)生,調(diào)節(jié)胃酸的分泌,促進胃腸蠕動。另外,激活辣椒素受體,還可抑制毛干的增殖,近年來發(fā)現(xiàn)他介導(dǎo)腫瘤細胞的凋亡。
產(chǎn)品圖片
Sample: Spinal cord (Mouse) Lysate at 40 ug Primary: Anti-TRPV1 (bs-23926R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 92 kD Observed band size: 92 kD
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TRPV1) Polyclonal Antibody, Unconjugated (bs-23926R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TRPV1) Polyclonal Antibody, Unconjugated (bs-23926R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Mouse stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TRPV1) Polyclonal Antibody, Unconjugated (bs-23926R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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