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Rabbit Anti-TRPC6  antibody (bs-21380R)  
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產(chǎn)品編號(hào) bs-21380R
英文名稱 Rabbit Anti-TRPC6  antibody
中文名稱 瞬時(shí)受體電位離子通道蛋白6抗體
別    名 MTRP6; Short transient receptor potential channel 6; si:rp71-1p14.9; Transient Receptor Potential Cation Channel Subfamily C Member 6; Transient receptor protein 6; TRP 6; TRP-6; TRP6; TRPC 6; TrpC6; TRPC6_HUMAN; TRRP6; bZ1P14.9; FLJ11098; FLJ14863; FSGS2.  
Specific References  (2)     |     bs-21380R has been referenced in 2 publications.
[IF=5.702] Song Qiaoli. et al. Neuroprotective Effects of Estrogen Through BDNF-Transient Receptor Potential Channels 6 Signaling Pathway in the Hippocampus in a Rat Model of Perimenopausal Depression. FRONT AGING NEUROSCI. 2022 Jul;0:675  IF ;  Rat.  
[IF=2.832] Songchao Xu. et al. Dexmedetomidine Alleviates Neuropathic Pain via the TRPC6-p38 MAPK Pathway in the Dorsal Root Ganglia of Rats. J PAIN RES. 2022; 15: 2437–2448  WB ;  Rat.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Rabbit)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 106kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRPC6: 831-931/931 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq].

Subunit:
Interacts with MX1 and RNF24.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.
Contains 4 ANK repeats.

SWISS:
Q9Y210

Gene ID:
7225

Database links:

Entrez Gene: 7225 Human

Entrez Gene: 22068 Mouse

Entrez Gene: 89823 Rat

Omim: 603652 Human

SwissProt: Q9Y210 Human

SwissProt: Q61143 Mouse

Unigene: 159003 Human

Unigene: 325086 Mouse

Unigene: 105986 Rat



產(chǎn)品圖片
Sample: A549(Human) Cell Lysate at 30 ug Primary: Anti-TRPC6 (bs-21380R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 106 kD Observed band size: 106 kD
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