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Rabbit Anti-IL17RA  antibody (bs-23053R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-23053R
英文名稱 Rabbit Anti-IL17RA  antibody
中文名稱 白介素17受體抗體
別    名 Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; hIL-17R; IL-17R; MGC10262; CD217; CDw217; IL17 RECEPTOR; IL17FR; AW538159; I17RA_HUMAN.  
研究領(lǐng)域 細(xì)胞膜受體  細(xì)胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 92kDa
細(xì)胞定位 細(xì)胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-17R/IL-17RA/CD217: 168-178/864aa <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. [provided by RefSeq]

Function:
Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Glycosylated.

DISEASE:
Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Similarity:
Contains 1 SEFIR domain.

SWISS:
Q60943

Gene ID:
16172

Database links:

Entrez Gene: 23765 Human

Entrez Gene: 16172 Mouse

Omim: 605461 Human

SwissProt: Q96F46 Human

SwissProt: Q60943 Mouse

Unigene: 48353 Human

Unigene: 4481 Mouse



產(chǎn)品圖片
Sample: Thymus (Mouse) Lysate at 40 ug Primary: Anti- CD217 (bs-23053R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 92 kD Observed band size: 120 kD
Sample: SiHa (Human) Cell Lysate at 30 ug Primary: Anti-17R’IL-17RA’CD217 (bs-23053R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 120 kD Observed band size: 120 kD
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