| 產(chǎn)品編號(hào) | bsm-51526M |
| 英文名稱 | Mouse Anti-SERPINC1 antibody |
| 中文名稱 | SERPINC1單克隆抗體 |
| 別 名 | AntithrombinIII; Antithrombin III; Antithrombin-III; AT 3; AT III; AT3; ATIII; MGC22579; Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1; Serine Proteinase Inhibitor Clade C Member 1; SERPIN C1; Serpin peptidase inhibitor clade C (antithrombin) member 1; ATH III; Antithrombin 3; ANT3_HUMAN. |
| 研究領(lǐng)域 | 心血管 細(xì)胞生物 合成與降解 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | A22D1 |
| 交叉反應(yīng) | Rat (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-1000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 51kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SERPINC1: 31-120/464 |
| 亞 型 | IgG1 |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]. Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Subunit: Forms protease inhibiting heterodimer with TMPRSS7. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Plasma. Post-translational modifications: Phosphorylation sites are present in the extracellular medium.. Similarity: Belongs to the serpin family. SWISS: P01008 Gene ID: 462 Database links: Entrez Gene: 462 Human SwissProt: P01008 Human |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Rat Liver tissue lysates
Primary: Anti-SERPINC1 (bsm-51526M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 58 kD
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