吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
久久精品国产,国产综合精品
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Mouse Anti-Tau-4  antibody (bsm-41722M)  
~~~促銷代碼KT202411~~~
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
200ug(PBS only)/5600.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bsm-41722M
英文名稱 Mouse Anti-Tau-4  antibody
中文名稱 微管相關(guān)蛋白Tau-4單克隆抗體
別    名 MAPT; Microtuble-associted protein Tau; AI413597; AW045860; DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FLJ31424; FTDP 17; FTDP17; G Protein beta 1 gamma 2 subunit interacting factor 1; G protein beta1/gamma2 subunit interacting factor 1; MAPTL; MGC134287; MGC138549; MGC156663; Microtubule associated protein tau isoform 4; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; PHF tau; PHF-tau; PPND; pTau; RNPTAU; Tauopathy and respiratory failure, included; microtubule-associated protein tau isoform 4; TAU_HUMAN; Isoform Tau-F; 2N4R  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 6E2
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:400-800,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant Human Tau-4 Protein: 1-441/441 
亞    型 IgG3
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Function:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Subunit:
Interacts with SQSTM1 when polyubiquitinated (By similarity). Interacts with PSMC2 through SQSTM1. Interacts with FKBP4. Binds to CSNK1D (By similarity). Interacts with SGK1 (By similarity).

Subcellular Location:
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Tissue Specificity:
Expressed in neurons and at a lower level in the liver and kidney. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

DISEASE:
Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylations.

Defects in MAPT are a cause of frontotemporal dementia (FTD) [MIM:600274]; also called frontotemporal dementia (FTD), pallido-ponto-nigral degeneration (PPND) or historically termed Pick complex. This form of frontotemporal dementia is characterized by presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons.

Similarity:
Contains 4 Tau/MAP repeats.

SWISS:
P10636-8

Gene ID:
4137

Database links:

Entrez Gene: 281296 Cow

Entrez Gene: 4137 Human

Entrez Gene: 17762 Mouse

Entrez Gene: 29477 Rat

Omim: 157140 Human

SwissProt: P29172 Cow

SwissProt: P10636 Human

SwissProt: P10637 Mouse

SwissProt: P19332 Rat

Unigene: 101174 Human

Unigene: 1287 Mouse

Unigene: 2455 Rat



tau蛋白是腦內(nèi)神經(jīng)元細(xì)胞支架蛋白之一.其正常功能是促進(jìn)微管蛋白組成微管,并維持已形成微管的穩(wěn)定性.參與維持細(xì)胞形態(tài)、信息傳遞、細(xì)胞分裂等重要生物學(xué)過程,是軸突生長發(fā)育和神經(jīng)元極性形成的不可缺少因素.
近年來發(fā)現(xiàn)tau蛋白與一些中樞神經(jīng)系統(tǒng)變性疾病密切相關(guān),尤其是神經(jīng)Tau具有啟動(dòng)微管系統(tǒng)的裝配以及穩(wěn)定微管系統(tǒng)的作用,該蛋白的錯(cuò)誤折疊與老年性癡呆等神經(jīng)退行性疾病密切相關(guān).
產(chǎn)品圖片
25 ug total protein per lane of various lysates (see on figure) probed with Tau-4 monoclonal antibody, unconjugated (bsm-41722M) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
Paraformaldehyde-fixed, paraffin embedded Human Breast Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Human Tau-4 Monoclonal Antibody, Unconjugated(bsm-41722M) at 1:200overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Human Tau-4 Monoclonal Antibody, Unconjugated(bsm-41722M) at 1:200overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Breast; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Human Tau-4 Monoclonal Antibody, Unconjugated(bsm-41722M) at 1:200overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Human Tau-4 Monoclonal Antibody, Unconjugated(bsm-41722M) at 1:200overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Human Tau-4 Monoclonal Antibody, Unconjugated(bsm-41722M) at 1:200overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
嗯灬啊灬把腿张开灬A片| 亚洲国产精品一区二区WWW| 国产第一页屁屁影院| 无码国产精成人午夜视频一区二区| 黑人巨大精品欧美一区二区 | 欧美最猛黑人XXXXX猛交| 精品人妻伦一二三区久久| 欧美交换国产一区内射| 拍摄av现场失控高潮数次| 国模冰莲自慰肥美胞极品人体图 | 成人免费无遮挡无码黄漫视频| 蜜臀AV在线| 免费无码国产V片在线观看| 亚洲精品中文字幕乱码三区| 99精品国产一区二区| 中文字日产幕码三区的做法大全| 99精产国品一二三产区| 亚洲午夜AV久久久精品影院色戒| 女性女同性AⅤ免费观女性恋| 国产成A人亚洲精V品无码| 天天做天天爱天天综合网2021| 国产精品国产三级国产A| 久久精品国产亚洲AV忘忧草18| 精品久久久久久久免费人妻| 一性一交一口添一摸视频| 亚洲AV无码国产精品色午友在线| 又粗又黄又猛又爽大片免费| 狠狠色综合7777久夜色撩人| 欧美超级乱婬视频播放| 国产精品视频一区| 成人H动漫精品一区二区无码| 成人动漫在线| 国内精品视频一区二区三区八戒 | 一女大战七个黑人到喷浆| 特级毛片爽WWW免费版| 欧美精品一区二区少妇免费A片| 无码日本精品XXXXXXXXX| 欧美乱熟人妻色情影视| 亚洲熟妇无码另类久久久| 中文无码熟妇人妻AV在线| 永久黄网站色视频免费直播|