| 產(chǎn)品編號(hào) | V1201 |
| 英文名稱 | Human MPO |
| 中文名稱 | 髓過氧化物酶單克隆抗體 |
| 別 名 | Myeloperoxidase; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN. |
| 理論分子量 | 84kDa |
| 性 狀 | Liquid |
| 緩 沖 液 | 0.01M PBS(pH7.4) |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014] 髓過氧化物酶MPO,作為一種白細(xì)胞酶,具有介導(dǎo)炎性反應(yīng)、調(diào)節(jié)免疫應(yīng)答等多種功能,并可參與疾病的發(fā)生發(fā)展過程。同時(shí),髓過氧化物酶基因存在基因多態(tài)性,也影響機(jī)體對(duì)疾病的易感性. 在正常淋巴組織中和各種髓樣細(xì)胞增生癥中，MPO均有較強(qiáng)表達(dá)，如：淋巴樣細(xì)胞、原核細(xì)胞、肥大細(xì)胞、漿細(xì)胞以及各種上皮源性腫瘤和肉瘤等。 髓過氧化物酶(myeloperoxidase,MPO),是一種血紅素蛋白，富含于中性粒細(xì)胞中,由粒細(xì)胞進(jìn)入循環(huán)之前在骨髓內(nèi)合成并存儲(chǔ)于噬天青顆粒內(nèi)。外界刺激可導(dǎo)致中性粒細(xì)胞聚集，從而釋放髓過氧化物酶。M |
