| 產(chǎn)品編號(hào) | bs-24706R |
| 英文名稱 | Rabbit Anti-IGFBP5 antibody |
| 中文名稱 | 胰島素樣生長(zhǎng)因子結(jié)合蛋白5抗體 |
| 別 名 | IBP 5; IBP5; IGF binding protein 5; IGF BP5; Insulin Like Growth Factor Binding Protein 5; IBP5_HUMAN; Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 糖尿病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 30kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGFBP5: 171-270/272 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development. Subcellular Location: Secreted. Tissue Specificity: Osteosarcoma, and at lower levels in liver, kidney and brain. Similarity: Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain. SWISS: P24593 Gene ID: 3488 Database links: Entrez Gene: 3488 Human Entrez Gene: 16011 Mouse Omim: 146734 Human SwissProt: P24593 Human SwissProt: Q07079 Mouse Unigene: 607212 Human Unigene: 405761 Mouse Unigene: 1593 Rat 生長(zhǎng)因子和激素（ Growth Factor and Hormones） IGFBP5胰島素樣生長(zhǎng)因子結(jié)合蛋白5(IGFBP-5)是一種可以與胰島素樣生長(zhǎng)因子(IGFs)結(jié)合的分泌性蛋白,其通過IGFs調(diào)節(jié)細(xì)胞的生長(zhǎng)、分化、凋亡、黏附和運(yùn)動(dòng),IGFBP-5與IGFs結(jié)合可以調(diào)節(jié)IGFs與IGF-I型受體間的相互作用,改變其促有絲分裂效應(yīng)、凋亡抑制效應(yīng)和促細(xì)胞運(yùn)動(dòng)作用。 有人認(rèn)為：由于造骨細(xì)胞能表達(dá)與IGF-1受體截然不同的IGFBP-5受體，IGFBP-5本身也是一種生長(zhǎng)因子，能夠不依賴IGF-I獨(dú)立作用來調(diào)節(jié)骨代謝。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Kidney (Mouse) Tissue Lysate at 40 ug
Lane 2: Cerebrum (Mouse) Tissue Lysate at 40 ug
Lane 3: Hela (Human) Cell Lysate at 30 ug
Lane 4: HepG2 (Human) Cell Lysate at 30 ug
Lane 5: MCF-7 (Human) Cell Lysate at 30 ug
Primary:
Anti-IGFBP5 (bs-24706R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 30 kD
Observed band size: 28 kD
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