吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯(lián)系我們
51国偷自产一区二区三区,国产免费内射又粗又爽密桃视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-ROCK1(Thr455+Ser456)/Cy5 Conjugated antibody (bs-4630R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4630R-Cy5
英文名稱1 Rabbit Anti-phospho-ROCK1(Thr455+Ser456)/Cy5 Conjugated antibody
中文名稱 Cy5標記的磷酸化Rho相關蛋白激酶1抗體
別    名 p-ROCK1(Thr455/Ser456); p160 ROCK1; p160ROCK; Renal carcinoma antigen NY REN 35; Rho associated coiled coil containing protein kinase 1; Rho associated protein kinase 1; Rho-associated coiled-coil containing protein kinase 1; ROCK1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Horse, Rabbit, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 158kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human ROCK1 around the phosphorylation site of Thr455/Ser456
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq].

Function:
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.

Subunit:
Homodimer. Interacts with RHOB, RHOC, MYLC2B snd PTEN (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, DAPK3, GEM, JIP3, RHOE, PPP1R12A, PFN1, LIMK1, LIMK2 and TSG101. Interacts with FHOD1 in a Src-dependent manner.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, centrosome, centriole (By similarity). Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Note=Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes.

Tissue Specificity:
Detected in blood platelets.

Post-translational modifications:
Autophosphorylated on serine and threonine residues. Phosphorylated upon DNA damage, probably by ATM or ATR.
Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 protein kinase domain.
Contains 1 REM (Hr1) repeat.

Database links:

Entrez Gene: 6093 Human

Entrez Gene: 19877 Mouse

Entrez Gene: 81762 Rat

Omim: 601702 Human

SwissProt: Q8MIT6 Cow

SwissProt: Q13464 Human

SwissProt: P70335 Mouse

SwissProt: Q63644 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ROCK1也是絲/蘇氨基酸激酶的一種,可調節(jié)細胞因子,促進平滑肌收縮和肌動蛋白的形成,因此又稱:含有卷曲螺旋的蛋白激酶。目前主要用于腫瘤浸潤、轉移方面的研究。
版權所有 2004-2026 www.xucheq.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
人妻含泪让粗大挺进| 无码精品人妻一区二区三区人妻斩| 最近中文字幕国语免费高清6| 国产精品亚洲一区二区无码| 97精品国产一区二区三区| 人妻丰满熟妇无码区免费| 久久久精品人妻无码专区不卡| 丰满熟妇乱又伦| 我的变态室友(H)三攻一受| 欧洲成人午夜精品无码区久久| 国产人妻777人伦精品HD| 国产一国产看免费高清片| 欧美性大战久久久久久久| 极品尤物一区二区三区| 欧美特黄A级高清免费大片A片 | 久久精品国产亚洲av麻豆| 啦啦啦高清影视在线观看视频| 国产成人精品一区二区三区视频 | 在线观看国产一区二区三区| 欧洲亚洲国产精华液| 草草久久久无码国产专区| 无码粉嫩小泬无套在线观看A片 | 成人自慰女黄网站免费大全| 无码国产69精品久久久久网站| 午夜精品久久久久久久 | JZZIJZZIJ亚洲乱熟无码| chinesemature老熟妇高潮| 熟妇少妇任你躁在线无码| 国产片XXXXA片国语对白| 草草久久久无码国产专区| av片在线播放| 朋友销魂的人妻| 久久AV无码精品人妻出轨| 亚洲AV无码一区二区三区网站| 国产精品日本一区二区在线播放| 亚洲午夜久久久久久久久电影网| 中文字幕人成无码人妻综合社区| 国产99久久九九精品无码| 国产精品久久久久久吹潮| 99国产精品久久久久久久成人热 | 极品新婚夜少妇真紧|