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Rabbit Anti-Rab25/Gold Conjugated antibody (bs-6501R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6501R-Gold
英文名稱1 Rabbit Anti-Rab25/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的癌基因RAS相關(guān)蛋白R(shí)ab25抗體
別    名 CATX 8; CATX-8; CATX8; member RAS oncogene family; RAB25; RAB-25; RAB25_HUMAN; Ras related protein Rab 25; Ras-related protein Rab-25.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  腫瘤細(xì)胞生物標(biāo)志物  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Rab25 (145-190aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface

Function:
Involved in the regulation of cell survival. Promotesinvasive migration of cells in which it functions to localize andmaintain integrin alpha-V/beta-1 at the tips of extendingpseudopodia. Increases the rates of ovarian and breast cancersprogression and aggressiveness by modulating cellular processessuch as proliferation, survival and migration of epithelial tumorcells. May selectively regulate the apical recycling pathway.Together with MYO5B regulates transcytosis

Subunit:
Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 andRAB11FIP4. Interacts (via the hypervariable C-terminal region) withITGB1 (via the cytoplasmic region); the interaction isGTP-dependent. Interacts with ITGAV. Associates with the integrinalpha-V/beta-1 heterodimer.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmicside (Potential). Cell projection, pseudopodium membrane.Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1in vesicles at the pseudopodial tips.

Tissue Specificity:
Expressed in ovarian epithelium (NOE) andbreast tissue. Expressed in ovarian cancer; expression is increasedrelative to NOE cells. Expression in ovarian cancer is stagedependent, with stage III and stage IV showing higher levels thanearly stage cancers. Expressed in breast cancer; expression isincreased relative to normal breast tissue.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Database links:

Entrez Gene: 57111 Human

Entrez Gene: 53868 Mouse

Omim: 612942 Human

SwissProt: P57735 Human

SwissProt: Q9WTL2 Mouse

SwissProt: P46629 Rabbit

Unigene: 632469 Human

Unigene: 26994 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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