| 產(chǎn)品編號 | bs-6502R-PE |
| 英文名稱1 | Rabbit Anti-Testin/PE Conjugated antibody |
| 中文名稱 | PE標(biāo)記的腫瘤抑制基因Testin抗體 |
| 別 名 | Testin; TES; TESS 2; TESS; TESS2; TESS-2; Testis derived transcript (3 LIM domains); Testis derived transcript; TES_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 鋅指蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Testin (161-210aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Cancer-associated chromosomal changes often involveregions containing fragile sites. This gene maps to a commomfragile site on chromosome 7q31.2 designated FRA7G. This gene issimilar to mouse Testin, a testosterone-responsive gene encoding aSertoli cell secretory protein containing three LIM domains. LIMdomains are double zinc-finger motifs that mediate protein-proteininteractions between transcription factors, cytoskeletal proteinsand signaling proteins. This protein is a negative regulator ofcell growth and may act as a tumor suppressor. This scaffoldprotein may also play a role in cell adhesion, cell spreading andin the reorganization of the actin cytoskeleton. Multiple proteinisoforms are encoded by transcript variants of this gene. Function: Scaffold protein that may play a role in cell adhesion,cell spreading and in the reorganization of the actin cytoskeleton.Plays a role in the regulation of cell proliferation. May act as atumor suppressor. Inhibits tumor cell growth. Subunit: Interacts via LIM domain 1 with ZYX. Interacts (via LIMdomain 3) with ENAH and VASP. Interacts with talin, actin,alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) withACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimerinteracts with ENAH to form a heterotrimer. Subcellular Location: Cytoplasm. Cell junction, focal adhesion.Note=Detected along actin stress fibers. Tissue Specificity: Ubiquitous. Similarity: Belongs to the prickle / espinas / testin family. Contains 3 LIM zinc-binding domains. Contains 1 PET domain. Database links: Entrez Gene: 26136 Human Entrez Gene: 21753 Mouse Omim: 606085 Human SwissProt: Q2QLB2 Horse SwissProt: Q9UGI8 Human SwissProt: P47226 Mouse Unigene: 592286 Human Unigene: 664957 Human Unigene: 436548 Mouse Unigene: 44847 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
