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Rabbit Anti-Neurogenin 3/BF488 Conjugated antibody (bs-0922R-BF488)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0922R-BF488
英文名稱1 Rabbit Anti-Neurogenin 3/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的神經(jīng)元素3抗體
別    名 NGN3; neurogenin 3; Neurog3; Neurogenin3; Neurogenin-3; ATH4B; Atoh5; Math4B; NEUROG3; ngn3; OTTHUMP00000019730; Protein atonal homolog 5.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NGN3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm.

Function:
Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.

Subcellular Location:
Nucleus.

DISEASE:
Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4) [MIM:610370]. DIAR4 is a characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:

Entrez Gene: 50674 Human

Entrez Gene: 11925 Mouse

Entrez Gene: 60329 Rat

Omim: 604882 Human

SwissProt: Q9Y4Z2 Human

SwissProt: P70661 Mouse

Unigene: 532682 Human

Unigene: 57236 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)生物學(xué)相關(guān)蛋白(Neurobiology)
Ngn3屬于bHLH家族蛋白,是胰腺發(fā)育過(guò)程中短暫表達(dá)的蛋白,可能是胰腺內(nèi)分泌細(xì)胞系的定向因子,一般在成熟胰島中不存在。
Ngn3的表達(dá)會(huì)導(dǎo)致胰腺內(nèi)分泌細(xì)胞數(shù)的增加外分泌細(xì)胞數(shù)的減少。因而胰島β細(xì)胞并不是完全靠干細(xì)胞分化產(chǎn)生,主要是通過(guò)已分化胰島β細(xì)胞的分裂增殖。
但近年來(lái),有學(xué)者認(rèn)為:Ngn3雖在胰腺發(fā)育中短暫表達(dá),但是否存在使胰島干細(xì)胞或前體細(xì)胞自我更新的能力尚未明確定論。
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