吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
丝袜老师办公室里做好紧好爽,迷人的后妈韩国中文,免费人妻精品一区二区三区
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-LEF1(Ser42)/PE-Cy5.5 Conjugated antibody (bs-9842R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-9842R-PE-Cy5.5
英文名稱1 Rabbit Anti-phospho-LEF1(Ser42)/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的磷酸化淋巴增強因子-1抗體
別    名 LEF1 (phospho S42); LEF1 (phospho Ser42); p-LEF1(phospho S42); p-LEF1(Ser42); lymphoid enhancing factor-1; Transcription factor T cell specific 1 alpha ; DKFZp586H0919; LEF 1; LEF1; Lymphoid enhancer binding factor 1; T cell specific transcription factor 1 alpha; TCF 1 alpha; TCF1 alpha; TCF1alpha; TCF1-alpha; LEF1_HUMAN; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  發(fā)育生物學(xué)  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human LEF1 around the phosphorylation site of Ser42
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

Function:
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Subunit:
Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK.

Subcellular Location:
Nucleus. Note=Found in nuclear bodies upon PIASG binding.

Tissue Specificity:
Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.

Post-translational modifications:
Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.

Similarity:
Belongs to the TCF/LEF family.
Contains 1 HMG box DNA-binding domain.

Database links:

Entrez Gene: 51176 Human

Omim: 153245 Human

SwissProt: Q9UJU2 Human

Unigene: 726506 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

lef-1是淋巴增強因子/T-細胞因子(LEF/TCF)家族的成員之一,屬于高遷移率組分蛋白家族。lef-1也是一個重要的轉(zhuǎn)錄因子,是Wnt信號通路的核心成分。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
尤物视频在线观看| 久久久久99精品成人片试看| 日日躁夜夜躁狠狠躁| 中文字幕日韩欧美一区二区三区| JAPANESEHD熟女熟妇| 欧美在线 | 亚洲| 丝袜美腿一区二区三区| 国产亚洲精品久久久一区| 日韩精品无码一区二区中文字幕 | 亚洲AV无码国产精品麻豆天美| 熟睡人妻被讨厌的公侵犯| 国产综合精品| 偷偷色噜狠狠狠狠的777米奇| 欧美高清性xxxxhdvideosex | 中文字幕一区二区| 全免费A级毛片免费看网站| 国产成人精品无码一区二区| 欧美另类69xxxxx| 日韩乱码人妻无码系列中文字幕| 国产50部艳色禁片无码| 偷玩同学漂亮麻麻张嫣| 精精国产XXXX视频在线播放| 国产AV无码专区亚洲AV毛网站| 免费AV在线| 久久人妻无码毛片A片麻豆| 6080YYY午夜理论AA片| 成人毛片18女人毛片免费看| 欧美艳星NIKKI激情办公室| 女人扒开屁股桶爽30分钟| 狠狠人妻久久久久久综合蜜桃| 熟妇少妇任你躁在线无码| 成 人 免费 黄 色 视频| 亚洲日韩国产精品乱-久| 国产看黄网站又黄又爽又色 | 亚洲AV无码专区在线播放中文| 公交车上~嗯啊被高潮| 久久久久久久精品无码AV少妇| 午夜福利视频| 特黄做受又粗又大又硬老头| 蜜臀av国产精品久久久久| 中文字幕一区二区人妻|