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Rabbit Anti-Glutathione Reductase/PE-Cy5 Conjugated antibody (bs-0837R-PE-Cy5)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0837R-PE-Cy5
英文名稱1 Rabbit Anti-Glutathione Reductase/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的谷胱甘肽還原酶抗體
別    名 glutathione reductase; GLUR; Glutathione reductase mitochondrial; GR; Gr1; GRase; GRD 1; GRD1; GSR; MGC78522; GSHR_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 免疫學  激酶和磷酸酶  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Glutathione Reductase
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.

Function:
Maintains high levels of reduced glutathione in the cytosol.

Subunit:
Homodimer; disulfide-linked.

Subcellular Location:
Isoform Mitochondrial: Mitochondrion.
Isoform Cytoplasmic: Cytoplasm.

Similarity:
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Database links:

Entrez Gene: 2936 Human

Entrez Gene: 14782 Mouse

Entrez Gene: 116686 Rat

Omim: 138300 Human

SwissProt: P00390 Human

SwissProt: P47791 Mouse

SwissProt: P70619 Rat

Unigene: 271510 Human

Unigene: 283573 Mouse

Unigene: 19721 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胱甘肽還原酶為一種黃素酶,可催化氧化型谷胱甘肽轉(zhuǎn)變成還原型谷胱甘肽(GSH),從而提高細胞液中GSH的含量。
GSH具有抵抗自由基氧化對機體損傷的作用,GSH的重要生理功能在于能還原體內(nèi)生成的過氧化氫(H2O2)。GSH的儲量與創(chuàng)傷、腫瘤等的預后,以及人體衰老有關(guān)。
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