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Rabbit Anti-CD13/RBITC Conjugated antibody (bs-1383R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1383R-RBITC
英文名稱1 Rabbit Anti-CD13/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的CD13氨肽酶N抗體
別    名 ANPEN; Aminopeptidase N; Alanyl aminopeptidase; Alanyl membrane aminopeptidase; Aminopeptidase M; Aminopeptidase N; ANPEP; APN; CD 13; CD13 antigen; gp150; hAPN; Lap 1; Lap1; Alanyl (membrane) aminopeptidase; AMPN_HUMAN; AP M; AP N; AP-M; AP-N; CD13; LAP 1; LAP1; PEPN; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; p150.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  干細胞  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 109kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD13
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. Expressed in epithelial cells. Belongs to the peptidase M1 family.

Function:
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

Subunit:
Homodimer. Interacts with the S1 domain of HCoV-229E spike protein.

Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol (Potential). Note=A soluble form has also been detected.

Tissue Specificity:
Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.

Post-translational modifications:
Sulfated.
N- and O-glycosylated.
May undergo proteolysis and give rise to a soluble form.

Similarity:
Belongs to the peptidase M1 family.

Database links:

Entrez Gene: 290 Human

Entrez Gene: 16790 Mouse

Entrez Gene: 81641 Rat

Omim: 151530 Human

SwissProt: P15144 Human

SwissProt: P97449 Mouse

SwissProt: P15684 Rat

Unigene: 1239 Human

Unigene: 4487 Mouse

Unigene: 11132 Rat

Unigene: 179371 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

氨肽酶N(又稱CD13)是氨肽酶系列的一種,氨肽酶是從蛋白質(zhì)多肽鏈氨基端催化降解氨基酸殘基的水解蛋白酶。是多種冠狀病毒的受體,目前在腫瘤侵襲、轉(zhuǎn)移、免疫調(diào)節(jié)和病毒感染等多方面受人們的關(guān)注.它在腫瘤細胞表面高水平表達,對腫瘤細胞外基底膜起到降解作用引發(fā)腫瘤的侵襲和轉(zhuǎn)移。主要分布于小腸和腎臟,巨噬細胞、粒細胞和中樞神經(jīng)系統(tǒng)的突觸膜也表達CD13.
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