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Rabbit Anti-Cyclin G/APC Conjugated antibody (bs-1389R-APC)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1389R-APC
英文名稱(chēng)1 Rabbit Anti-Cyclin G/APC Conjugated antibody
中文名稱(chēng) APC標(biāo)記的周期素G抗體
別    名 CCNG 1; CCNG; CCNG1; CYCG1; Cyclin G; CCNG1_HUMAN; Cyclin-G; Cyclin G1; CyclinG1; Cyclin-G1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號(hào)  細(xì)胞周期蛋白  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin G
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1. Peak expression of cyclin G2 is seen in late S phase, as opposed to cyclin G1 expression, which is constitutive.

Function:
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).

Subcellular Location:
Nucleus. DNA replication foci after DNA damage.

Tissue Specificity:
High levels in skeletal muscle, ovary, kidney and colon.

Similarity:
Belongs to the cyclin family. Cyclin G subfamily.

Database links:

Entrez Gene: 900 Human

Omim: 601578 Human

SwissProt: P51959 Human

Unigene: 79101 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cyclin G的生物功能還沒(méi)有完全清楚,他是細(xì)胞周期蛋白家族中近來(lái)發(fā)現(xiàn)的新成員,也是已知的唯一受到腫瘤抑制基因p53調(diào)控的細(xì)胞周期蛋白。
近年來(lái)經(jīng)研究發(fā)現(xiàn),Cyclin G可能有促進(jìn)細(xì)胞增長(zhǎng)的作用,在細(xì)胞增殖和神經(jīng)再生中的可能起到一定的作用。
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