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Rabbit Anti-Arfaptin 2/FITC Conjugated antibody (bs-1442R-FITC)
訂購(gòu)熱線:400-901-9800
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訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1442R-FITC
英文名稱1 Rabbit Anti-Arfaptin 2/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的ADP核糖基化因子結(jié)合蛋白2抗體
別    名 ARFIP2; arfaptin 2; ADP-ribosylation factor interacting protein 2; Partner of RAC1; POR1; ARFP2_HUMAN .  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 轉(zhuǎn)運(yùn)蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Arfaptin 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
ARFIP2 is a ubiquitously expressed protein implicated in mediating cross talk between RAC and ARF small GTPases. It has been shown that ARFIP2 binds specifically to GTP-bound ARF1 and ARF6, but binds to Rac-GTP and Rac-GDP with similar affinities. The X-ray structure of arfaptin reveals an elongated, crescent-shaped dimer of 3-helix coiled-coils. Structures of arfaptin with Rac bound to either GDP or the slowly hydrolysable analog GMPPNP show that the switch regions adopt similar conformations in both complexes.

Function:
Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.

Subunit:
Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Directly interacts with ARL1 GTP-bound form; this interaction leads to a > 4-fold increase in the amount of ARL1-bound GTP at steady state level.

Similarity:
Contains 1 AH domain.

Database links:

Entrez Gene: 23647 Human

Entrez Gene: 76932 Mouse

Entrez Gene: 293344 Rat

Omim: 601638 Human

SwissProt: P53365 Human

SwissProt: Q8K221 Mouse

SwissProt: Q6AY65 Rat

Unigene: 595146 Human

Unigene: 75139 Human

Unigene: 41637 Mouse

Unigene: 73878 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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