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Rabbit Anti-AAK1/Gold Conjugated antibody (bs-1507R-Gold)
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說(shuō) 明 書(shū): 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-1507R-Gold
英文名稱(chēng)1 Rabbit Anti-AAK1/Gold Conjugated antibody
中文名稱(chēng) 膠體金標(biāo)記的AP2關(guān)聯(lián)激酶1抗體
別    名 AAK 1; Adaptor associated kinase 1; Aak1; AAK1_HUMAN; Adaptor-associated kinase 1; AP2-associated protein kinase 1; DKFZp686F03202; AP2 associated kinase 1;AP2 associated protein kinase 1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; KIAA1048; MGC138170; MGC164568; MGC164570.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul(10nm  15nm  35nm
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  轉(zhuǎn)運(yùn)蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 104kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AAK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Function:
Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis.

Subunit:
Interacts with alpha-adaptin, AP-2, clathrin, NUMB andEPS15 isoform 2. Interacts with membrane-bound activated NOTCH1 butnot with the inactive full-length form of NOTCH1. Preferentiallyinteracts with monoubiquitinated activated NOTCH1 compared to thenon-ubiquitinated form.

Subcellular Location:
Cell membrane; Peripheral membrane protein(By similarity). Membrane, clathrin-coated pit (By similarity).Note=Active when found in clathrin-coated pits at the plasmamembrane. In neuronal cells, enriched at presynaptic terminals. Innon-neuronal cells, enriched at leading edge of migrating cells (Bysimilarity).

Tissue Specificity:
Detected in brain, heart and liver. Isoform 1is the predominant isoform in brain.

Post-translational modifications:
Autophosphorylated (By similarity).

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 22848 Human

Entrez Gene: 269774 Mouse

Entrez Gene: 500244 Rat

SwissProt: Q2M2I8 Human

SwissProt: Q3UHJ0 Mouse

SwissProt: P0C1X8 Rat

Unigene: 468878 Human

Unigene: 221038 Mouse

Unigene: 203307 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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