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Rabbit Anti-KCNG2/BF555 Conjugated antibody (bs-9857R-BF555)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-9857R-BF555
英文名稱1 Rabbit Anti-KCNG2/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的心臟鉀離子通道蛋白亞基2抗體
別    名 Cardiac potassium channel subunit; KCNG2; KCNG2_HUMAN; KV6.2; Potassium voltage-gated channel subfamily G member 2; Voltage-gated potassium channel subunit Kv6.2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  信號轉(zhuǎn)導(dǎo)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNG2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Neuronal and cardiac cells are excited by voltage-gated ion channels. Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. Mutations interfering with potassium ion channels are known to cause a variety of disorders. KCNG2 (potassium voltage-gated channel subfamily G member 2) is also known as voltage-gated potassium channel subunit KV6.2, cardiac potassium channel subunit or KCNF2 and is a 466 amino acid protein. KCNG2 is a multi-pass membrane protein abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and detected at lower concentrations in brain, lung and placenta. KCNG2 is an electrically silent subunit that forms heterodimers with KV2.1, creating a unique functional K+ channel. KCNG2-KV2.1 heterodimers are known to be inhibited by tetraethylammonium and propafenone. KCNG2 is thought to downregulate potassium channel currents because KCNG2-KV2.1 heterodimers generate smaller currents than KV2.1 homodimers

Function:
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

Subunit:
Heterodimer with KCNB1. Does not form homomultimers.

Subcellular Location:
Membrane.

Tissue Specificity:
Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.

Similarity:
Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.

Database links:

Entrez Gene: 26251 Human

Entrez Gene: 240444 Mouse

Entrez Gene: 307234 Rat

Omim: 605696 Human

SwissProt: Q9UJ96 Human

SwissProt: Q9QYU3 Rat

Unigene: 247905 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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