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Rabbit Anti-Persephin/BF555 Conjugated antibody (bs-1518R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1518R-BF555
英文名稱1 Rabbit Anti-Persephin/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的PSP抗體
別    名 PSPN_HUMAN; PSP.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 發(fā)育生物學(xué)  神經(jīng)生物學(xué)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Persephin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016]

Function:
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.

Subunit:
Homodimer; disulfide-linked.

Subcellular Location:
Secreted.

Similarity:
Belongs to the TGF-beta family. GDNF subfamily.

Database links:

Entrez Gene: 5623 Human

Omim: 602921 Human

SwissProt: O60542 Human

Unigene: 248159 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)生物學(xué)相關(guān)蛋白(Neurobiology)
PSP是TGF-β家族的一個新亞族,該亞族還有其他三個成員:Neurturin(NTN)、GDNF和Artemin(ART),它們均不同程度地對多巴胺神經(jīng)元、脊髓前角運(yùn)動神經(jīng)元、背根神經(jīng)節(jié)、頸上神經(jīng)節(jié)以及腎等非神經(jīng)元細(xì)胞都具有生長促進(jìn)作用。研究表明膠質(zhì)細(xì)胞系源性神經(jīng)營養(yǎng)因子,主要用于PD的研究。
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