吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产精品视频一区,综合久久,日本爽快片18禁片免费久久
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Cyclin D3/FITC Conjugated antibody (bs-0660R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0660R-FITC
英文名稱1 Rabbit Anti-Cyclin D3/FITC Conjugated antibody
中文名稱 FITC標記的周期素D3抗體
別    名 CCND3; CyclinD3; D3 type cyclin; G1 S specific cyclin D3; CCND3_HUMAN; G1/S-specific cyclin-D3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  細胞周期蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin D3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]..

Function:
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subunit:
Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.

Subcellular Location:
Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.

Post-translational modifications:
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Similarity:
Belongs to the cyclin family. Cyclin D subfamily.
Contains 1 cyclin N-terminal domain.

Database links:

Entrez Gene: 540547 Cow

Entrez Gene: 896 Human

Entrez Gene: 12445 Mouse

Entrez Gene: 25193 Rat

Omim: 123834 Human

SwissProt: Q3MHH5 Cow

SwissProt: P30281 Human

SwissProt: P30282 Mouse

SwissProt: P48961 Rat

Unigene: 534307 Human

Unigene: 27291 Mouse

Unigene: 472101 Mouse

Unigene: 3483 Rat

Unigene: 54319 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞周期素是周期素依賴激酶的調(diào)節(jié)因子,不同的細胞周期素控制著細胞周期中不同的特定階段。
周期素D3與周期素D1和D2一樣,為細胞周期中G1期進入S期的一個重要調(diào)控因子,通過激活CdK4或CdK6等作用,促進DNA合成,加速細胞增殖,主要用于B細胞淋巴瘤、乳腺癌、頭頸部鱗癌、食道癌、肝癌和肺癌等惡性腫瘤的研究。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
小SAO货揉揉你的奶真大视频 | 色综合久久精品亚洲国产| 欧美精品久久久久久久自慰| 插我一区二区在线观看| 国产一区二区三精品久久久无广告| 国产精品V欧美精品∨日韩| FREE性VIDEO西欧极品| 97精品久久久久中文字幕| 国产精品麻豆成人AV电影艾秋| 豆国产97在线 | 亚洲| 秘书喂奶好爽一边吃奶一| 日韩乱码人妻无码系列中文字幕| 亚洲香蕉成人AV网站在线观看 | 搡BBBB搡BBB搡| 中文字幕一区二区人妻| 亚洲国产精品一区二区久久HS| 天天躁日日躁狠狠躁| 18禁白丝喷水视频WWW视频| 欲妇荡岳丰满少妇A片24小时| 无码人妻一区二区三区免费视频| 免费人成无码大片在线观看| www亚洲精品少妇裸乳一区二区 | 国产亚洲精品一区二区在线观看 | 国产V综合V亚洲欧美久久| 亚洲精品国产精品乱码不99| 和山田进行LV999的恋爱| 漂亮人妻被黑人久久精品 | WWW亚洲精品少妇裸乳一区二区| 亚洲大尺度无码专区尤物| 麻花豆剧国产MV在视频播放| 无码性午夜视频在线观看| 亚洲精品乱码久久久久久蜜桃不卡| 成人国产亚洲精品A区天堂蜜臀 | 久久久99精品免费观看| 一边捏奶头一边啪高潮会怎么样| 欧美啪啪| 狠狠人妻久久久久久综合蜜桃| 99精品国产在热久久无码| 欧美巨大另类极品videosbest| 国产A国产片国产| 国产精品人人爽人人做我的可爱 |