吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
娇妻借朋友高H繁交H,A片人人澡C片人人人妻
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Cyclin D3/BF488 Conjugated antibody (bs-0660R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0660R-BF488
英文名稱1 Rabbit Anti-Cyclin D3/BF488 Conjugated antibody
中文名稱 BF488標記的周期素D3抗體
別    名 CCND3; CyclinD3; D3 type cyclin; G1 S specific cyclin D3; CCND3_HUMAN; G1/S-specific cyclin-D3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  細胞周期蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin D3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]..

Function:
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subunit:
Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.

Subcellular Location:
Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.

Post-translational modifications:
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Similarity:
Belongs to the cyclin family. Cyclin D subfamily.
Contains 1 cyclin N-terminal domain.

Database links:

Entrez Gene: 540547 Cow

Entrez Gene: 896 Human

Entrez Gene: 12445 Mouse

Entrez Gene: 25193 Rat

Omim: 123834 Human

SwissProt: Q3MHH5 Cow

SwissProt: P30281 Human

SwissProt: P30282 Mouse

SwissProt: P48961 Rat

Unigene: 534307 Human

Unigene: 27291 Mouse

Unigene: 472101 Mouse

Unigene: 3483 Rat

Unigene: 54319 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞周期素是周期素依賴激酶的調(diào)節(jié)因子,不同的細胞周期素控制著細胞周期中不同的特定階段。
周期素D3與周期素D1和D2一樣,為細胞周期中G1期進入S期的一個重要調(diào)控因子,通過激活CdK4或CdK6等作用,促進DNA合成,加速細胞增殖,主要用于B細胞淋巴瘤、乳腺癌、頭頸部鱗癌、食道癌、肝癌和肺癌等惡性腫瘤的研究。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
无码AV免费毛片一区二区| 亚洲AV无码专区国产乱码电影 | 少妇扒开粉嫩小泬视频| 把腿扒开让我添30分钟视频| 无码天堂亚洲国产AV久久| 亚洲精品99久久久久中文字幕| 熟女性饥渴一区二区三区| 少妇特黄A片一区二区三区蜜桃 | 亚洲成色WWW久久网站| 久久泄欲网| 少妇又紧又色又爽又刺激视频| 在线视频免费观看WWW动漫| 国模小黎自慰GOGO人体| 欧美变态口味重另类在线视频| 97久久精品人人澡人人爽| 黄桃AV无码免费一区二区三区| 亚洲午夜AV久久久精品影院色戒| 国产精品99久久久久久人| 国产亚洲成AV人片在线观黄桃| 久久精品国产亚洲av麻豆| 亚洲av永久无码精品| 亚洲AV日韩AV无码AV| 色琪琪女色窝77777| 久久综合亚洲色hezyo国产| 曰本女人与公GUO交酡视频A片| 亚洲午夜精品久久久久久APP| 国产精品美女久久久免费| 人妻少妇久久久久久97人妻| 午夜精品久久久久久久久| A片在线观看免费视频网站| 精品人伦一区二区三区蜜桃小说 | 国模杨依粉嫩蝴蝶150P| 亚洲AV乱码一区二区三区林ゆな | 最新精品国偷自产在线69| 无码免费一区二区三区免费播放| 军人全身脱精光自慰| 人妻 丝袜美腿 中文字幕 | 国产精品美女久久久久AV爽 | 无码精品A∨在线观看中文| AV电影网站| 狠狠综合久久AV一区二区 |