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Rabbit Anti-Cyclin D3/BF594 Conjugated antibody (bs-0660R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0660R-BF594
英文名稱1 Rabbit Anti-Cyclin D3/BF594 Conjugated antibody
中文名稱 BF594標記的周期素D3抗體
別    名 CCND3; CyclinD3; D3 type cyclin; G1 S specific cyclin D3; CCND3_HUMAN; G1/S-specific cyclin-D3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  細胞周期蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin D3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]..

Function:
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subunit:
Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.

Subcellular Location:
Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.

Post-translational modifications:
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Similarity:
Belongs to the cyclin family. Cyclin D subfamily.
Contains 1 cyclin N-terminal domain.

Database links:

Entrez Gene: 540547 Cow

Entrez Gene: 896 Human

Entrez Gene: 12445 Mouse

Entrez Gene: 25193 Rat

Omim: 123834 Human

SwissProt: Q3MHH5 Cow

SwissProt: P30281 Human

SwissProt: P30282 Mouse

SwissProt: P48961 Rat

Unigene: 534307 Human

Unigene: 27291 Mouse

Unigene: 472101 Mouse

Unigene: 3483 Rat

Unigene: 54319 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞周期素是周期素依賴激酶的調節(jié)因子,不同的細胞周期素控制著細胞周期中不同的特定階段。
周期素D3與周期素D1和D2一樣,為細胞周期中G1期進入S期的一個重要調控因子,通過激活CdK4或CdK6等作用,促進DNA合成,加速細胞增殖,主要用于B細胞淋巴瘤、乳腺癌、頭頸部鱗癌、食道癌、肝癌和肺癌等惡性腫瘤的研究。
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