| 產(chǎn)品編號 | bs-6684R-BF488 |
| 英文名稱1 | Rabbit Anti-SCN11A/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的鈉通道蛋白11α抗體 |
| 別 名 | hNaN; NaN; NAV1.9; Peripheral nerve sodium channel 5; PN 5; PN5; SCN 11A; SCN 12A; SCN12A; Sensory neuron sodium channel 2; SNS 2; SNS2; Sodium channel protein type 11 subunit alpha; Sodium channel protein type XI subunit alpha; Sodium channel voltage gated type XI alpha; Sodium channel voltage gated type XI alpha polypeptide; Sodium channel voltage gated type XI alpha subunit; Sodium channel voltage gated type XII alpha polypeptide; Voltage gated sodium channel Nav1.9; Voltage gated sodium channel subunit alpha Nav1.9; SCNBA_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 通道蛋白 細胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 197kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SCN11A/NAV1.9 (656-705aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Voltage gated sodium channels are membrane protein complexes that play a fundamental role in generating and transmitting action potentials in neuronal cells. SCN11A (Sodium channel, voltage gated, type XI, alpha subunit) mediates the voltage dependent sodium ion permeability and conductance. It forms the pore of the sodium selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin resistant sodium channel isoform. Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Subunit: he voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. Database links: Entrez Gene: 11280 Human Omim: 604385 Human SwissProt: Q9UI33 Human Unigene: 591657 Human Unigene: 30023 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
