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Rabbit Anti-CTAGE5/PE-Cy7 Conjugated antibody (bs-6808R-PE-Cy7)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6808R-PE-Cy7
英文名稱1 Rabbit Anti-CTAGE5/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的皮膚T細胞淋巴瘤相關(guān)抗原5抗體(腦膜瘤表達抗原6)
別    名 cTAGE 5A; cTAGE 5B; cTAGE 5C; cTAGE 5D; cTAGE family member 5; CTAGE family, member 5; CTAGE5; cTAGE5A; cTAGE5B; cTAGE5C; cTAGE5D; CTGE5_HUMAN; Cutaneous T cell lymphoma associated antigen 5; Cutaneous T-cell lymphoma-associated antigen 5; MEA11; MEA6; Meningioma expressed antigen 6 (coiled coil proline rich); Meningioma expressed antigen 6/11; Meningioma-expressed antigen 6/11; MGEA; MGEA11; MGEA6; Protein cTAGE 5; Protein cTAGE-5.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  淋巴細胞  t-淋巴細胞  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 91kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CTAGE5 (301-340aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Cutaneous T cell lymphomas (CTCL) represent a group of malignancies that originate from CD4-T lymphocytes and manifest on the skin. CTCL is a general term for several neoplasms including mycosis fungoides, T cell leukemia/ lymphoma and pagetoid reticulosis, all of which are very difficult to treat in the advanced stages. CTAGE2 (cutaneous T cell lymphoma associated-antigen 2) is a member of the cancer/testis antigen family of proteins (CTAGE) that, under normal conditions, are found primarily in the testis with little or no expression in other parts of the body. Another member of the CTAG family, namely CTAGE5 (also known as MEA11, MEA6, MGEA11 or MGEA6), is a tumor associated antigen that is found in tumors of various origins, including cutaneous T cell lymphomas. Both CTAGE2 and CTAGE5 are expressed as multiple isoforms due to alternative splicing events.

Function:
Tumor-associated antigen.Tissue specificity:Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.

Tissue Specificity:
Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.

DISEASE:
Note=Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

Similarity:
Belongs to the cTAGE family.

Database links:

Entrez Gene: 4253 Human

Omim: 602132 Human

SwissProt: O15320 Human

Unigene: 509200 Human

Unigene: 540038 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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