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Rabbit Anti-EDNRA/BF647 Conjugated antibody (bs-1757R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1757R-BF647
英文名稱1 Rabbit Anti-EDNRA/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的內(nèi)皮素受體A抗體
別    名 Endothelin receptor type A; EDNRA; Endothelin 1 receptor precursor; EDNR-A; Endothelin A receptor; Endothelin receptor type A; ET A; ETA; ET-A; ETA-R; ETA R; ETRA; hET AR; Ednra; EDNRA_HUMAN; Endothelin 1 specific receptor; Endothelin ET A receptor; Endothelin receptor ET1 specific type; Endothelin-1 receptor.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EDNRA
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Function:
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Subunit:
Interacts with HDAC7 and KAT5.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.

Database links:

Entrez Gene: 281749 Cow

Entrez Gene: 450187 Dog

Entrez Gene: 1909 Human

Entrez Gene: 13617 Mouse

Entrez Gene: 397457 Pig

Entrez Gene: 24326 Rat

GenBank: NM_001957 Human

GenBank: NM_174308 Human

GenBank: NM_012550 Rat

Omim: 131243 Human

SwissProt: P21450 Cow

SwissProt: Q5KSU9 Dog

SwissProt: P25101 Human

SwissProt: Q61614 Mouse

SwissProt: Q29010 Pig

SwissProt: P26684 Rat

Unigene: 183713 Human

Unigene: 283168 Mouse

Unigene: 392296 Mouse

Unigene: 10915 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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