吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产AV熟女一区二区三区,99久久久国产精品免费蜜臀,后入内射无码人妻一区
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-LEF-1/Gold Conjugated antibody (bs-1843R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1843R-Gold
英文名稱1 Rabbit Anti-LEF-1/Gold Conjugated antibody
中文名稱 膠體金標記的淋巴增強因子-1抗體
別    名 lymphoid enhancing factor-1; Transcription factor T cell specific 1 alpha ; DKFZp586H0919; LEF 1; LEF1; Lymphoid enhancer binding factor 1; T cell specific transcription factor 1 alpha; TCF 1 alpha; TCF1 alpha; TCF1alpha; TCF1-alpha; LEF1_HUMAN; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 免疫學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LEF-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

Function:
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Subunit:
Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK.

Subcellular Location:
Nucleus. Note=Found in nuclear bodies upon PIASG binding.

Tissue Specificity:
Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.

Post-translational modifications:
Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.

Similarity:
Belongs to the TCF/LEF family.
Contains 1 HMG box DNA-binding domain.

Database links:

Entrez Gene: 51176 Human

Omim: 153245 Human

SwissProt: Q9UJU2 Human

Unigene: 726506 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

lef-1是淋巴增強因子/T-細胞因子(LEF/TCF)家族的成員之一,屬于高遷移率組分蛋白家族。lef-1也是一個重要的轉(zhuǎn)錄因子,是Wnt信號通路的核心成分。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
88久久精品无码一区二区毛片| 小草影院| 韩国三级中文字幕HD久久精品| 夜夜添无码一区二区三区| 永久黄网站色视频免费直播| 精品人妻一区二区三区四区在线| 亚洲熟妇AV一区二区三区漫画| 日欧一片内射VA在线影院| CHINESE熟女熟妇1乱| 久久人妻内射无码一区三区| 少妇被粗大的猛烈进出免费视频 | 无码精品国产一区二区三区免费 | 999久久久国产精品| 国产中老年妇女精品| 性色AV浪潮AV色欲AV一区| 国模无码一区二区三区| 歪歪漫画网站页面入口弹窗秋蝉| 欧美顶级少妇做爰HD| 无码日本精品XXXXXXXXX| 无码人妻丰满熟妇区毛片| 野花高清完整版免费观看视频电视 | 男女无遮挡XX00动态图120秒| 久久99精品国产麻豆不卡| 久久综合狠狠综合久久综合88| 日韩夜夜高潮夜夜爽无码| 亚洲精品无码午夜福利中文字幕| 日本护士野外XXXHD| 久久久久久国产精品MV| 日韩亚洲AV人人夜夜澡人人爽| 人妻人人揉人人躁人人A片| 日本无码视频在线观看| 中国美女撒尿TXXXX视频偷窥| 国产色综合天天综合网| 小SAO货叫大声点奶真大| 又白又嫩毛又多15P| 日产一区二区| 小莹乳液汁水停电了还能用吗| 亚洲AV无码乱码国产精品久久| 人妻无码中文字幕| 成熟女人毛片WWW免费版在线| 99精品久久毛片A片|