吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
人物动物交互狗AA,国产成人一区二区三区影,国内精品卡一卡二卡三
Rabbit Anti-GFI1B/Biotin Conjugated antibody (bs-9881R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-9881R-Bio
英文名稱1 Rabbit Anti-GFI1B/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的自主生長(zhǎng)因子1B抗體
別    名 Potential regulator of CDKN1A translocated in CML; GFI 1B; GFI-1B; gfi1b; GFI1B protein; GFI1B_HUMAN; Growth factor independent 1B protein; Growth factor independent protein 1B; Potential regulator of CDKN1A; Translocated in CML; Zinc finger protein Gfi-1b.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  生長(zhǎng)因子和激素  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GFI1B
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

Function:
Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

Subunit:
Component of a RCOR-GFI-KDM1A-HDAC complex. Interacts directly with RCOR1, KDM1A and HDAC2 (By similarity). Forms a complex with GATA1. Interacts with histone methyltransferases EHMT2 and SUV39H1. Interacts with ARIH2 (via RING-type 2). Interacts with RUNX1T1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in bone marrow and fetal liver, but also detectable in fetal spleen, fetal thymus, and testes. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Overexpressed in bone marrow of patients with erythroleukemia and megakaryocytic leukemia as well as in their corresponding leukemic cell lines, and markedly repressed in severe aplastic anemia (SAA).

Post-translational modifications:
Methylation at Lys-8 in the SNAG domain seems required for the recruitment of the corepressor complex.

Similarity:
Contains 6 C2H2-type zinc fingers.

Database links:

Entrez Gene: 8328 Human

Omim: 604383 Human

SwissProt: Q5VTD9 Human

Unigene: 553160 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产又粗又大成人片在线观看| 校花不着寸缕的跪趴在地下视频| 97精品国产一区二区三区| 学长被C哭着爬走又被拉回来| 亚洲欧美国产精品无码中文字| 亚洲色无码A片一区二区潘甜甜| 玩弄人妻少妇500系列视频 | 51精产一二三产区区别| 日韩毛片无码永久免费看| 青柠在线影院观看日本| 窝窝午夜精品一区二区| 亚洲AV无码久久| 高潮又爽又无遮挡又免费| 亚洲一区二区三区无码久久| 久久精品AⅤ无码中文字字幕重口 精品无码人妻一区二区免费蜜桃 女人被躁到高潮免费视频 | GOGO人体| 欧美成年黄网站色视频| 久久久欧美精品激情| 一边摸一边做爽的视频17国产| 老熟妇仑乱视频一区二区| 无码一区二区三区| 国产50部艳色禁片无码| 最新精品国偷自产在线69| 永久黄网站色视频免费直播| 国产成A人亚洲精V品无码| 香蕉久久夜色精品升级完成 | 午夜亚洲AV永久无码精品| 精品久久欧美熟妇WWW| 国产又粗又猛又黄又爽无遮挡| 全免费A级毛片免费看| 亚洲AV成人片色在线观看高潮| 粉嫩av国产一区二区三区| 四十路の五十路熟女豊満| 花房姑娘免费观看全集| 欧美性xxxxx极品娇小| 亚洲AV综合色区无码专区桃色| 美国СЕКС| 肉乳乱无码A片观看免费| 少妇被躁爽到高潮无码人狍大战 | 亚洲国产精品一区二区久久HS| 挺进邻居丰满少妇的身体|