| 產(chǎn)品編號 | bs-2415R-AP |
| 英文名稱1 | Rabbit Anti-Ankyrin G/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的錨定蛋白G抗體 |
| 別 名 | ANK-3; ANK-3; ANK3; ANK3_HUMAN; ankyrin 3 (G); Ankyrin 3, node of Ranvier (ankyrin G); Ankyrin 3, node of Ranvier; Ankyrin G119; Ankyrin-3; Ankyrin-G; brain specific ankyrin G; CHANK3. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 細(xì)胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 481/220kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Ankyrin G |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: human: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized. [provided by RefSeq] mouse: This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Function: In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Subunit: Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres (By similarity). Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG. Subcellular Location: Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane (By similarity). Lysosome (By similarity). Note=In skeletal muscle, localized at costameres and neuromuscular junctions (By similarity). In macrophages, associated with lysosomes (By similarity). Tissue Specificity: Expressed in brain, neurons and other tissues. DISEASE: Note=Genetic variations in ANK3 are associated with autism spectrum disorders susceptibility. Similarity: Contains 23 ANK repeats. Contains 1 death domain. Contains 2 ZU5 domains. Database links: Entrez Gene: 288 Human Entrez Gene: 11735 Mouse Omim: 600465 Human SwissProt: Q12955 Human SwissProt: G5E8K5 Mouse SwissProt: Q4U206 Mouse Unigene: 499725 Human Unigene: 235960 Mouse Unigene: 202383 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 錨定蛋白G是一個分子量在480KDa大分子細(xì)胞內(nèi)蛋白。 錨蛋白(ankyrin)錨蛋白屬于聯(lián)結(jié)蛋白家族,廣泛存在于各種組織細(xì)胞中。錨蛋白連接整合膜蛋白到細(xì)胞骨架蛋白網(wǎng)絡(luò),在多種細(xì)胞功能活動中起關(guān)鍵作用,參與機體生長、發(fā)育、細(xì)胞內(nèi)蛋白轉(zhuǎn)運、細(xì)胞極性的建立和維持、細(xì)胞黏附、信號傳導(dǎo)以及mRNA轉(zhuǎn)錄等。 |
