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Rabbit Anti-CD20/AP Conjugated antibody (bs-4869R-AP)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4869R-AP
英文名稱1 Rabbit Anti-CD20/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的CD20抗體
別    名 CD20_HUMAN; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1; MS4A2; B1; CVID5; LEU-16; S7.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  干細(xì)胞  細(xì)胞表面分子  細(xì)胞類型標(biāo)志物  淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, )
產(chǎn)品應(yīng)用 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD20
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CD20 is a non glycosylated protein with a molecular weight of 35 or 37 kDa depending on the degree of phosphorylation. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit.

Function:
This protein may be involved in the regulation of B-cell activation and proliferation.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed on B-cells.

Post-translational modifications:
Phosphorylated. Might be functionally regulated by protein kinase(s).

DISEASE:
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Similarity:
Belongs to the MS4A family.

Database links:

Entrez Gene: 931 Human

Omim: 112210 Human

SwissProt: P11836 Human

Unigene: 712553 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD20是B細(xì)胞特異性抗原,其表達(dá)呈細(xì)胞類型一種質(zhì)膜蛋白質(zhì),參與信號(hào)傳導(dǎo)作用,此抗體識(shí)別大多數(shù)B細(xì)胞上的一種抗原。多用于標(biāo)記B淋巴細(xì)胞及B細(xì)胞淋巴瘤。 CD20一般不與T細(xì)胞交叉反應(yīng),對(duì)B細(xì)胞淋巴瘤和急慢性淋巴細(xì)胞白血病等有較好的細(xì)胞特異性,因此在惡性淋巴瘤,尤其是T或B細(xì)胞淋巴瘤的分類上,CD20是最常用的B細(xì)胞標(biāo)志。
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