| 產(chǎn)品編號 | bs-0624R-BF488 |
| 英文名稱1 | Rabbit Anti-CD272/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的B和T淋巴細(xì)胞衰減蛋白抗體 |
| 別 名 | B and T lymphocyte associated protein; B and T lymphocyte attenuator; B and T lymphocyte associated; BTLA; BTLA1; CD272 antigen; FLJ16065; MGC129743; BTLA_HUMAN; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD272. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 淋巴細(xì)胞 t-淋巴細(xì)胞 b-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, ) |
| 產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human B and T-lymphocyte attenuator |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). Function: Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. Subunit: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Post-translational modifications: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 151888 Human Entrez Gene: 208154 Mouse Omim: 607925 Human SwissProt: Q7Z6A9 Human SwissProt: Q7TSA3 Mouse Unigene: 445162 Human Unigene: 38199 Mouse Unigene: 124474 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. BTLA對T細(xì)胞的活化、增殖起著重要的負(fù)調(diào)控作用，BTLA相應(yīng)配體為TNFR超家族中的皰疹病毒入侵介質(zhì)（HVEM）, 其表達(dá)于包括T細(xì)胞在內(nèi)的多種免疫細(xì)胞表面。 有學(xué)者將他定為CD28的超級族成員，B、T淋巴細(xì)胞衰減子-CD272主要用于細(xì)胞信號傳導(dǎo)方面的研究。 近來國外學(xué)者對BTLA用于抑制腫瘤方面的研究也有了新的進(jìn)展，認(rèn)為B、T淋巴細(xì)胞衰減子對腫瘤的生長有抑制作用，探索新的腫瘤免疫治療有了新的途徑， 封閉此途徑有可能成為腫瘤免疫治療的新靶點。 |
