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Rabbit Anti-BMP10/Gold Conjugated antibody (bs-9447R-Gold)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-9447R-Gold
英文名稱1 Rabbit Anti-BMP10/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的骨形態(tài)發(fā)生蛋白10抗體
別    名 BMP-10; Bmp10; BMP10_HUMAN; Bone morphogenetic protein 10; Bone morphogenetic protein 10 preproprotein; MGC126783.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 心血管  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 12kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BMP10
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Bone morphogenic proteins (BMPs) are members of the TGF beta superfamily and are involved in the induction of cartilage and bone formation. BMP-10 (Bone morphogenetic protein 10) is a 424 amino acid secreted protein that exists as a disulfide-linked homodimer. Expressed specifically in heart tissue, BMP-10 functions to prevent the premature activation of p57 (a negative cell cycle regulator), thereby maintaining the proliferative activity of embryonic cardiomyocytes and playing a critical role in the formation of trabeculae within the developing heart. Additionally, BMP-10 inhibits the growth and migration of endothelial cells and functions as a ligand for ALK-1, a protein that is tightly linked to angiogenesis. This suggests that, in addition to its role in cardiomyocyte formation, BMP-10 participates in the formation of blood vessels in developing cardiac muscle.

Function:
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.

Subunit:
Homodimer; disulfide-linked.

Subcellular Location:
Secreted.

Similarity:
Belongs to the TGF-beta family.

Database links:

Entrez Gene: 27302 Human

Entrez Gene: 12154 Mouse

Entrez Gene: 500245 Rat

Omim: 608748 Human

SwissProt: O95393 Human

SwissProt: Q9R229 Mouse

SwissProt: Q4AEG6 Rat

Unigene: 158317 Human

Unigene: 483321 Mouse

Unigene: 118010 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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