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Rabbit Anti-Musashi 1/PE Conjugated antibody (bs-11201R-PE)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11201R-PE
英文名稱1 Rabbit Anti-Musashi 1/PE Conjugated antibody
中文名稱 PE標(biāo)記的神經(jīng)干細(xì)胞RNA結(jié)合蛋白Musashi1抗體
別    名 Musashi 1 / Msi1; Msi 1; Msi1; Msi-1; MSI1H_HUMAN; Musashi homolog 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  干細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Musashi 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Musashi1 (Msi1) is an RNA-binding protein expressed in neural progenitor cells and neural stem cells. Msi1 is the mammalian homolog of Drosophila Musashi. The gene encoding human Msi1 encodes a 362 amino acid protein. In murine embryonic neural progenitor cells, Msi1 localizes to the cytoplasm and is downregulated during differentiation. Msi1 binds to NUMB, which encodes a membrane-associated antagonist of Notch signaling. Msi1 appears to function in the proliferation and maintenance of stem cell populations of the central nervous system. In addition to its usefulness as a marker for neural progenitor cells in normal human brains, Msi1 is also a marker for human gliomas. In rats, Msi1 is expressed in Sertoli cells of the testis and granulosa cells of the ovary.

Function:
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.

Similarity:
Belongs to the Musashi family.
Contains 2 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 4440 Human

Entrez Gene: 17690 Mouse

Entrez Gene: 259272 Rat

Omim: 603328 Human

SwissProt: O43347 Human

SwissProt: Q61474 Mouse

SwissProt: Q8K3P4 Rat

Unigene: 158311 Human

Unigene: 5077 Mouse

Unigene: 162146 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Musashi1是一種進(jìn)化保守的RNA結(jié)合蛋白,在維持干細(xì)胞狀態(tài)、分化和腫瘤發(fā)生方面起著重要作用。Musashi1 選擇性地表達(dá)在神經(jīng)前體細(xì)胞上,包括神經(jīng)干細(xì)胞上。在神經(jīng)系統(tǒng)外,Musashi1還是腸干細(xì)胞的選擇性標(biāo)記。這些組織干細(xì)胞或未成熟細(xì)胞Musashi1的表達(dá),表明Musashi1在轉(zhuǎn)錄后基因調(diào)節(jié)階段維持這些細(xì)胞未分化狀態(tài)起重要作用。Musashi1過(guò)度表達(dá)通過(guò)依賴RBP2Jk的旁路激活Notch1,而Notch信號(hào)途徑功能為誘導(dǎo)哺乳動(dòng)物神經(jīng)干細(xì)胞自我更新。通過(guò)musashi1-P-小鼠培養(yǎng)腦細(xì)胞的Musashi蛋白產(chǎn)物反義去除研究,發(fā)現(xiàn)這些基因在維持神經(jīng)干細(xì)胞未分化狀態(tài)起著重要的作用。 Musashi抑制m-Numb轉(zhuǎn)錄的分子機(jī)制尚待進(jìn)一步研究。Musashi1有可能除轉(zhuǎn)錄調(diào)控外還參與其他調(diào)控途徑。另外,Musashi1還表達(dá)在一些腦腫瘤的特殊類型(這些腫瘤可能起源自非成熟腦細(xì)胞),并且表達(dá)水平和腫瘤的惡性程度及增殖能力相關(guān)。
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