吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
久久无码人妻精品一区二区三区,2022最新韩国理伦片在线观看
Rabbit Anti-RFC1/RBITC Conjugated antibody (bs-11304R-RBITC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11304R-RBITC
英文名稱1 Rabbit Anti-RFC1/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的復(fù)制激活因子C1抗體
別    名 DNA binding Protein PO GA; DNA-binding protein PO-GA; MHC binding factor beta; MHCBFB; RECC1; Replication factor C 140 kDa subunit; Replication factor C; Replication factor C large subunit; Replication factor C subunit 1; Replication factor C1; RF-C 140 kDa subunit; RFC1; RFC1_HUMAN; RFC140; RFC140 Replication Factor C 140 kDa subunit; A1 140 kDa subunit; A1 P145 Activator 1 large subunit; Activator 1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞凋亡  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 128kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RFC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Replication factor C (RFC) is an essential DNA polymerase accessory protein that is required for numerous aspects of DNA metabolism, including DNA replication, DNA repair and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction. All five of the RFC subunits share a set of related sequences (RFC boxes) that include nucleotide-binding consensus sequences. Four of the five RFC genes (including RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas the RFC1 subunit does not. RFC1 is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during FAS-mediated apoptosis. In addition, phosphorylation of the PCNA binding domain of RFC1 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibits DNA synthesis. The human RFC1 gene maps to chromosome 4p14 and encodes the RFC1 subunit.

Function:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.

Subunit:
Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA.

Subcellular Location:
Nucleus.

Tissue Specificity:
Wide tissue distribution. Undetectable in placental tissue.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the activator 1 large subunit family.
Contains 1 BRCT domain.

Database links:

Entrez Gene: 422788 Chicken

Entrez Gene: 5981 Human

Entrez Gene: 19687 Mouse

Entrez Gene: 89809 Rat

Omim: 102579 Human

SwissProt: P35251 Human

SwissProt: P35601 Mouse

Unigene: 507475 Human

Unigene: 148877 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
久久久久久久99精品免费观看| 国产精品亚洲一区二区三区| 99久久久精品免费观看国产| 斗罗大陆在线全集免费看| 业余 自由 性别 成熟偷窥| 重口老太大和小伙乱| 人妻体体内射精一区二区| 鲁一鲁一鲁一鲁一澡| 中文字幕被公侵犯的漂亮人妻 | 中文字幕亚洲无线码在线一区| 少妇被又大又粗又爽毛片久久黑人| 中文无码熟妇人妻AV在线| 玩弄高耸白嫩的乳峰A片| 挺进绝色邻居的紧窄小肉| 亚洲老熟女AV一区二区在线播放| 日韩AV高清无码| 永久免费AV无码网站性色AV| 无码国产精品一区二区免费16| 少妇又色又紧又爽又刺激视频| 啊灬啊灬啊灬快灬深用力| 少妇被躁爽到高潮无码人狍大战| 欧美性受XXXX| 国产人久久人人人人爽| 大肉大捧一进一出好爽视频MBA| 国模无码视频一区二区三区| 国产真人无遮挡作爱免费视频| 国产sm调教视频在线观看| 国产精品久久久久久久| 亚洲V欧美V国产V在线观看| 国产成A人亚洲精V品无码| 中国丰满人妻VIDEOSHD| 男人J桶进女人P无遮挡全过程| 熟妇与小伙子MATUR老熟妇E| 中国人妻被两个老外三P| 日本又色又爽又黄的A片18禁| 亚州av| 舌尖伸入湿嫩蜜汁呻吟A片视频| 小鲜肉吃小鲜肉的大LOGO| 一区二区乱子伦在线播放 | 中文字幕被公侵犯的漂亮人妻 | 日韩一卡2卡3卡4卡|