| 產(chǎn)品編號(hào) | bs-11594R-APC |
| 英文名稱1 | Rabbit Anti-Nicalin/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的γ-分泌酶組件蛋白NCLN抗體 |
| 別 名 | NCLN; NCLN_HUMAN; NET59; Nicalin; Nicalin homolog (zebrafish); Nicastrin like protein; Nicastrin-like protein. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nicalin (401-500aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype. Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Subunit: Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. Similarity: Belongs to the nicastrin family. Database links: Entrez Gene: 56926 Human Entrez Gene: 103425 Mouse Omim: 609156 Human SwissProt: Q969V3 Human SwissProt: Q8VCM8 Mouse Unigene: 657032 Human Unigene: 302791 Mouse Unigene: 4202 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Nicastrin(NCT)是高度糖基化的I型跨膜蛋白,是γ-分泌酶復(fù)合物的重要組件蛋白之一,廣泛分布于人類或鼠的所有細(xì)胞類型。它不僅與γ-分泌酶的組裝和成熟密切相關(guān),其構(gòu)象及表達(dá)變化對(duì)γ-分泌酶活性和阿爾茨海默病(Alzheimer's disease,AD)中β淀粉樣蛋白(amyloid proteinβ,Aβ)的產(chǎn)生及降解也起重要調(diào)節(jié)作用。 |
