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Rabbit Anti-CALHM1/RBITC Conjugated antibody (bs-11642R-RBITC)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11642R-RBITC
英文名稱1 Rabbit Anti-CALHM1/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的鈣平衡調(diào)節(jié)蛋白1抗體
別    名 CAHM1_HUMAN; Calcium homeostasis modulator 1; Calcium homeostasis modulator protein 1; CALHM1; FAM26C; Family with sequence similarity 26, member C; MGC39514; MGC39617; Protein FAM26C.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  通道蛋白  細胞膜蛋白  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CALHM1/FAM26C
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010].

Function:
May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.

Subunit:
Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures.

Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Colocalizes with HSPA5 at the endoplasmic reticulum.

Tissue Specificity:
Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.

Similarity:
Belongs to the FAM26 family.

Database links:

Entrez Gene: 255022 Human

Entrez Gene: 546729 Mouse

Entrez Gene: 499367 Rat

Omim: 612234 Human

SwissProt: Q8IU99 Human

Unigene: 680365 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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