| 產(chǎn)品編號(hào) | bs-11682R-BF488 |
| 英文名稱1 | Rabbit Anti-IMP4/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的膜內(nèi)蛋白酶4抗體 |
| 別 名 | SPPL2B; IMP4; Signal peptide peptidase-like 2B; Intramembrane protease 4; Protein SPP-like 2B; SPPL2B; SPP2B_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 泛素 Alzheimer's |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPPL2B (55-135aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: The SPPLs are a group of aspartic proteases that are responsible for proteolysis of type II membrane-anchored signalling factors. SPPL2b, unlike other SPPL family members is found in endosomes/lysosomes, and not the endoplasmic reticulum, and has a role in catalysing intramembrane cleavage of tumour necrosis factor alpha (TNFalpha). Subunit: Monomer. Homodimer. Interacts with ITM2B and TNF. Subcellular Location: Membrane; multi-pass membrane protein of endosomes/lysosomes. Tissue Specificity: Expressed predominantly in adrenal cortex and mammary gland. Post-translational modifications: Glycosylated. Similarity: Belongs to the peptidase A22B family. Contains 1 PA (protease associated) domain. Database links: Entrez Gene: 56928 Human SwissProt: Q8TCT7 Human Unigene: 330742 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
