| 產(chǎn)品編號(hào) | bs-2162R-AP |
| 英文名稱1 | Rabbit Anti-DKK1/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的抑癌蛋白DKK1抗體 |
| 別 名 | Dickkopf 1; Dickkopf 1 like; Dickkopf homolog 1; Dickkopf related protein 1; DKK 1; hDkk 1; hDkk1; DKK-1; SK. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Dog, (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DKK1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008] Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Subcellular Location: Secreted. Tissue Specificity: Placenta. Similarity: Belongs to the dickkopf family. Database links: Entrez Gene: 22943 Human Entrez Gene: 13380 Mouse Omim: 605189 Human SwissProt: O94907 Human SwissProt: O54908 Mouse Unigene: 40499 Human Unigene: 214717 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DKK1是一種分泌蛋白，也是Wnt信號(hào)途徑的一個(gè)抑制蛋白，在多種惡性腫瘤細(xì)胞系中高度表達(dá)，在腫瘤的發(fā)生、發(fā)展中有重要作用. |
