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Rabbit Anti-Pleiotrophin/Gold Conjugated antibody (bs-2444R-Gold)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書(shū): 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-2444R-Gold
英文名稱(chēng)1 Rabbit Anti-Pleiotrophin/Gold Conjugated antibody
中文名稱(chēng) 膠體金標(biāo)記的多效生長(zhǎng)因子抗體
別    名 pleiotrophin; HARP; HBBM; HBGAM; HBGF8; HBNF; HBNF1; Heparin Binding Growth Factor 8; Heparin binding neurite outgrowth promoting factor 1; heparin-binding growth associated molecule; NEGF1; Neurite Growth Promoting Factor 1; OSF-1; osteoblast-specific factor; PTN; PTN_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTN
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Pleiotrophin is a heparin-binding growth factor involved in the differentiation and proliferation of neuronal tissue during embryogenesis, and also secreted by melanoma and breast carcinoma cells. Pleiotrophin exhibits mitogenic and angiogenic properties and has been shown to influence the vascular supply, expansion and metastasis of tumour cells.

Function:
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Subunit:
Interacts with ALK and NEK6.

Subcellular Location:
Secreted.

Tissue Specificity:
Osteoblast and brain.

Post-translational modifications:
Phosphorylated by NEK6.

Similarity:
Belongs to the pleiotrophin family.

Database links:

Entrez Gene: 5764 Human

Entrez Gene: 19242 Mouse

Entrez Gene: 24924 Rat

Omim: 162095 Human

SwissProt: P21246 Human

SwissProt: P63089 Mouse

SwissProt: P63090 Rat

Unigene: 371249 Human

Unigene: 279690 Mouse

Unigene: 1653 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

多效生長(zhǎng)因子(pleiotrophin)是一種分泌性的生長(zhǎng)因子,具有促進(jìn)腫瘤細(xì)胞的增殖與遷移,對(duì)腫瘤血管的生成有促進(jìn)作用。
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