吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  人才招聘  關于我們  聯(lián)系我們
99国产精品无码,A级毛片无码久久精品免费 ,无码少妇精品一区二区免费动态
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-eIF4E (Ser209)/Cy3 Conjugated antibody (bs-2446R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2446R-Cy3
英文名稱1 Rabbit Anti-phospho-eIF4E (Ser209)/Cy3 Conjugated antibody
中文名稱 Cy3標記的磷酸化真核翻譯起始因子4E抗體
別    名 eIF4E(phospho S209); eIF4E(phospho Ser209); p-eIF4E(Ser209); EIF4F; eIF-4E; eIF 4E; CBP; eIF 4F 25 kDa subunit; CBP; eIF 4E; eIF 4F 25 kDa subunit; EIF 4F; EIF4E1; EIF4EL1; EIF4F; Eukaryotic Translation Initiation Factor 4 E; Eukaryotic translation initiation factor 4E like 1; Messanger RNA Cap Binding Protein eIF 4E; IF4E_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領域 免疫學  信號轉(zhuǎn)導  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Daniorerio)
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human eIF4E around the phosphorylation site of Ser209 [SG(p-S)TT]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.

Function:
Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Subunit:
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1 (By similarity). Interacts with Lassa virus Z protein. Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA.

Subcellular Location:
Cytoplasm, P-body.

Post-translational modifications:
Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.

Similarity:
Belongs to the eukaryotic initiation factor 4E family.

Database links:

Entrez Gene: 1977 Human

Entrez Gene: 13684 Mouse

Entrez Gene: 117045 Rat

Omim: 133440 Human

SwissProt: P06730 Human

SwissProt: P63073 Mouse

SwissProt: P63074 Rat

Unigene: 249718 Human

Unigene: 3941 Mouse

Unigene: 11275 Rat





Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

EIF4E是蛋白合成的一個主要調(diào)控因子,它表達量增加會促進多種腫瘤的生長的增值、分化,因此EIF4E是一種非常重要的抗癌藥物靶標。
版權所有 2004-2026 www.xucheq.com 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
69久久无码一区人妻A片| 国产免费无码又爽又刺激A片| 无码人妻少妇色欲AV一区二区| 国产亚洲AV综合人人澡精品| 少妇被粗大的猛烈进出免费视频 | 国产精品另类激情久久久免费| 国产成人无码精品久久久免费| 欧美三级A做爰在线观看| 无码专区AAAAAA免费视频| 久久久久亚洲精品无码网址 | 麻花传媒剧国产MV网站| 欧美色图片区| 极品粉嫩小泬白浆20PA片| 欧美不卡一区二区三区| 国产AV一区二区三区日韩| 漂亮人妻被黑人久久精品| 国产精品美女WWW爽爽爽视频| 日韩AV高清在线观看| 久久ER99热精品一区二区| 国产免费无码又爽又刺激A片| 亚洲色无码A片一区二区潘甜甜| 天天干天天日| 色一情一乱一伦一区二区三区| 亚洲AV无码专区在线观看下载| 精品久久久久久无码中文字幕一区| 亚洲中文字幕无码爆乳AV久久| 男阳茎进女阳道视频大全| 亚洲AV无码国产精品永久一区 | 久久久精品一区AAA片| 中字幕视频在线永久在线观看免费| 成人H动漫精品一区二区无码| 锕锕锕锕锕锕锕好多水社区| 免费无遮挡禁18污污网站| 丰满少妇张开大白腿| 国产老妇伦国产熟女老妇视频| 一个人看的www免费视频| 国产裸拍裸体视频在线观看| 永久免费精品精品永久-夜色| 日韩精品视频一区二区三区| 又湿又紧又大又爽A视频| 日日麻批免费40分钟无码|