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Rabbit Anti-ICOS ligand/Cy3 Conjugated antibody (bs-2471R-Cy3)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2471R-Cy3
英文名稱1 Rabbit Anti-ICOS ligand/Cy3 Conjugated antibody
中文名稱 Cy3標(biāo)記的誘導(dǎo)協(xié)同刺激分子配體CD275抗體
別    名 B7 H2; B7 homolog 2; B7 homologue 2; B7 like protein Gl50; B7 related protein 1; B7-like protein Gl50; B7-related protein 1; B7-H2; B7H2; B7RP 1; B7RP-1; B7RP1; CD 275; CD275; CD275 antigen; GL 50; GL50; ICOS L; ICOS LG; ICOS ligand; ICOSL; ICOSL_HUMAN; Icoslg; Inducible T cell co stimulator ligand; KIAA0653; LICOS; Transmembrane protein B7 H2 ICOS ligand; ICOSLG; ICOS ligand-like; ICOS ligand.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞表面分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ICOS ligand
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
ICOS ligand is a member of the B7 family and the immunoglobulin superfamily. Human ICOS ligand is expressed by activated monocytes/macrophages and dendritic cells. It binds to a CD28 like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. This interaction plays an important role in the T cell costimulation pathway.

Function:
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Subunit:
Membrane; Single-pass type I membrane protein.

Subcellular Location:
Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 23308 Human

Entrez Gene: 50723 Mouse

Omim: 605717 Human

SwissProt: O75144 Human

SwissProt: Q9JHJ8 Mouse

Unigene: 14155 Human

Unigene: 17819 Mouse




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

B7協(xié)同刺激分子及其相應(yīng)受體結(jié)合所產(chǎn)生的信號(hào)在調(diào)節(jié)T細(xì)胞活化及效應(yīng)性細(xì)胞因子分泌中起重要作用,具有負(fù)性調(diào)節(jié)作用的協(xié)同刺激分子對(duì)免疫應(yīng)答的適度進(jìn)行、防止自身免疫疾病的發(fā)生具有重要作用。
B7H2可協(xié)同刺激CD14 + 細(xì)胞增殖,并分泌IL-4、IL-5、IFN-β、TNF-α、GM-CSF和IL-10等細(xì)胞因子,但不能協(xié)同刺激T細(xì)胞上調(diào)IL-2的分泌。
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