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Rabbit Anti-CD151/RBITC Conjugated antibody (bs-2524R-RBITC)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2524R-RBITC
英文名稱1 Rabbit Anti-CD151/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的CD151抗體
別    名 CD151 antigen; CD151 molecule; GP27; Membrane glycoprotein SFA1; MER2; PETA3; Platelet endothelial tetraspan antigen 3; RAPH; SFA 1; SFA1; Tetraspanin24; TSPAN24; CD151_HUMAN; Platelet-endothelial tetraspan antigen 3; PETA-3; Tetraspanin-24; Tspan-24; CD151.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  細(xì)胞膜受體  細(xì)胞粘附分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Cow, Horse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD151
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008].

Function:
Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.

Subunit:
Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.

DISEASE:
Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

Database links:

Entrez Gene: 977 Human

Omim: 602243 Human

SwissProt: P48509 Human

Unigene: 654379 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD151蛋白是四跨膜超家族蛋白(transmembrane-4 superfamily,TM4SF)成員,參與調(diào)節(jié)細(xì)胞的形態(tài)和極性、促進(jìn)細(xì)胞黏附和遷移,并在體外血管形成中發(fā)揮著重要作用,該蛋白與血管新生有關(guān)。
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