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Rabbit Anti-CD112/PE-Cy5.5 Conjugated antibody (bs-2679R-PE-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2679R-PE-Cy5.5
英文名稱1 Rabbit Anti-CD112/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的細(xì)胞粘附分子CD112抗體
別    名 Nectin-2; Nectin2; Nectin 2; CD 112; CD112; CD112 antigen; Herpes virus entry mediator B; Herpes virus entry protein B; Herpesvirus entry mediator B; Herpesvirus entry protein B; Hve B; HveB; Poliovirus receptor like 2; Poliovirus receptor related 2 (herpesvirus entry mediator B); Poliovirus receptor related 2; Poliovirus receptor related protein 2; Poliovirus receptor-related protein 2; PRR 2; PRR2; PVRL 2; PVRL2; PVRL2_HUMAN; PVRR 2; PVRR2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  細(xì)胞粘附分子  細(xì)胞表面分子  內(nèi)皮細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Cow, Horse, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD112
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Nectin 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Can form trans-heterodimers with PVRL3/nectin-3.

Function:
Probable cell adhesion protein.

Subunit:
Can form trans-heterodimers with PVRL3/nectin-3. Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 5819 Human

Entrez Gene: 19294 Mouse

Entrez Gene: 308417 Rat

Omim: 600798 Human

SwissProt: Q92692 Human

SwissProt: P32507 Mouse

Unigene: 655455 Human

Unigene: 4341 Mouse

Unigene: 203297 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細(xì)胞粘附分子Nectin-2(CD112)是一種同源性非鈣依賴型的CAM,屬免疫球蛋白超家族,由nectin-1、nectin-2、nectin-3組成,廣泛存在于腫瘤、正常細(xì)胞,神經(jīng)細(xì)胞、內(nèi)皮細(xì)胞等,CD112也是單純皰疹病毒(HSV-1和HSV-2)的受體,具有同型或異型細(xì)胞粘附活性.在多發(fā)性硬化中呈現(xiàn)高表達(dá)。
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